Immunoablation Treatment with Support of HaematopoieticStem Cells in Refractory Forms of Multiple Sclerosis

Czech version

Authors: T. Kozák
Authors‘ workplace: Oddělení klinické hematologie FN KV, Praha, přednosta MUDr. L. Rosa, CSc. 2Neurologická klinika VFN, Praha, 3Neurologická klinika FN KV, Praha, 4Transfuzní oddělení FN KV, Praha, 5Ústav hematologie a krevní transfuze 1. LF UK, Praha ¹
Published in: Čes-slov Pediat 2000; (4): 187-190.
Category:

Overview

Immunosuppression and immunomodulation is a standard therapeutic strategy in the mana-gement of multiple sclerosis (MS). Advanced and rapidly progressive forms which do not respondto conventional type of therapy have a poor prognosis. Only 30% of patients confined toa wheelchair survive 10 years. High dose immunosuppressive therapy, immunoablation, withhaematopoietic stem cell support may be considered to arrest further progression of intractableforms of the disease. Here we present the results of this strategy in 10 patients. Toxicity of theprocedure was manageable. The primary goal was to stop progression. However, one patientimproved significantly, 3 patients improved slightly their EDSS, 6 patients improved theirSNRS. Improvement can occur several months after the procedure. One patient is progressingat her previous rate. In most patients, the dose of oral corticosteroids decreased significantly,further improving the quality of life.

Key words:
multiple sclerosis - treatment - immunoablation.

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