Atopic Patch Tests – Methods and Significance

Authors: J. Čelakovská 1;  K. Ettlerová 2;  K. Ettler 1;  J. Vaněčková 1
Authors‘ workplace: Klinika nemocí kožních a pohlavních FN a LF UK Hradec Králové přednosta doc. MUDr. Karel Ettler, CSc. 1;  Ambulance klinické imunologie a alergologie, Hradec Králové vedoucí MUDr. Květuše Ettlerová 2
Published in: Čes-slov Derm, 83, 2008, No. 2, p. 62-68
Category: Pharmacologyand Therapy, Clinical Trials


Atopic dermatitis is a chronic skin disease. Both immediate and delayed type of hypersensitivity plays role in its pathogenesis. The course of atopic dermatitis is complicated mostly by food allergens and aeroallergens, contact allergens, emotional, climatic and hormonal factors. Food allergy to cow milk and eggs has often been found in children under 3 years of age; however tolerance to these compounds is induced in majority (80%) of these patients after the age of three years. The food allergy in adult patients with atopic eczema has not been fully evaluated yet. Whereas immediate-type food reactions can be identified quite easily by evaluation of the specific IgE titres, the presence of the delayed hypersensitivity can be confirmed by atopy patch tests. The elaboration of atopic patch test methods and introducing such approach into the clinical practice could improve the diagnostic possibilities of food allergy and potentially replace the double blind, placebo controlled food challenge tests. The main task is the standardisation of food allergens in performing the tests.

Key words:
atopy – atopic dermatitis – food allergy – atopy patch tests


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