Recommendations for the treatment of psoriatic arthritis

Authors: J. Štolfa;  J. Vencovský;  K. Pavelka
Authors‘ workplace: Revmatologický ústav Praha
Published in: Čes. Revmatol., 24, 2016, No. 4, p. 142-152.
Category: Recomendation


The last recommendations for the treatment and monitoring of psoriatic arthritis were published by the Czech Society for Rheumatology five years ago, in 2011 [1]. Since then there has been a rapid evolution of new knowledge on all aspects of psoriatic disease, especially with regards to the extra-articular manifestations (enthesitis, dactylitis) and the comorbidities (especially metabolic syndrome, and cardiovascular disease). With a certain delay, compared to rheumatoid arthritis, attention was focused on a new treatment strategy aimed at early treatment initiation and determination of therapeutic targets. At the same time, we have witnessed an intensive research of new biological original drugs (boDMARDs) with a different mechanism of action than the inhibition of TNFα (eg. inhibitors of the p40 subunit of IL-12 / 23-ustekinumab, and inhibitors of IL-17 – secukinumab and ixekizumab), small molecules for oral administration (eg. inhibitor of phosphodiesterase 4 - apremilast, an inhibitor of JAK – tofacitinib), and finally, the introduction of biosimilar biological drugs (bsDMARDs). Following a similar update of EULAR recommendations, these aspects have raised the need to update the Recommendations of the Czech Society for Rheumatology as well.

Key words:
psoriatic arthritis, enthesitis, dactylitis, treatment recommendations, treatment strategy, activity indices, targets for therapy, biological therapy of PsA, ​​early treatment


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