Hematological manifestations in patients with systemic lupus erythematosus


Authors: M. Schubertová;  P. Horák;  M. Skácelová;  J. Zadražil
Authors‘ workplace: III. interní klinika – nefrologická, revmatologická a endokrinologická ;  Fakultní nemocnice, Olomouc
Published in: Čes. Revmatol., 24, 2016, No. 1, p. 6-14.
Category: Original article

Overview

Aim:
Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease characterized by hyperactivity of B cells and overproduction of organ nonspecific autoantibodies. The most common organ manifestations include impaired skin, kidneys, joints, cardiovascular system, central nervous system or hematologic manifestations. The aim of this study was to assess the incidence of hematological symptoms and their frequency in patients with SLE.

Patients and methods:
Single-center, retrospective study analyzed the incidence of hematologic manifestations in 160 patients who met the ACR diagnostic criteria for SLE. The presence and representation of hematologic manifestations was compared at the onset of the disease and at remission induction. The obtained data were statistically analyzed.

Results:
Hematologic manifestations were present in 67% of patients with SLE. The most common one, anemia, occurred early in the disease in 45% of patients with hemoglobin (Hb) levels of 101 ± 13 g / l and an average number of erythrocytes 3.50 ± 0.53 x 1012 / l. After stabilization of the disease the incidence of anemia decreased to 20% with a mean Hb value of 123 ± 18 g / l and the number of erythrocytes 3.9 ± 0.53 x 1012 / l. Hemolytic anemia was found in 21% of patients. Leucopenia was present in 24% of patients, the average number of leukocytes in these patients was 2.71 ± 0.71 x 109 / l. Twenty-four % of patients had thrombocytopenia and antiphospholipid syndrome was found in 16% of patients.

Conclusion:
Hematological abnormalities are among the most common manifestations of SLE. They represent one of the ACR and SLICC diagnostic criteria for SLE. Anemia, which affects almost half of the patients, was the most frequent abnormality.

Key words:
Systemic lupus erythematosus, hematopoiesis, anemia, antiphospholipid syndrome


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Dermatology & STDs Paediatric rheumatology Rheumatology
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