Efficacy and safety of intra-articular injection of depot corticosteroids in rheumatic diseases

Authors: R. Svobodová
Authors‘ workplace: Revmatologický ústav Praha
Published in: Čes. Revmatol., 23, 2015, No. 1, p. 22-32.
Category: Rewiev


Glucocorticoids play a very important role in the ­treatment of rheumatic diseases. In order to control the disease activity it is sometimes necessary to use relatively high doses of systemically administered glucocorticoids, which are associated with a number of serious side effects. Intra-articular or peri-articular steroid injections help manage pain and inflammatory conditions in a short time, minimizing these side effects. This work provides a summary of available intra-articular glucocorticoids and the comparison of their pharmacokinetics, pharmacodynamics, efficacy and safety in various rheumatic diseases and introduces triamcinolone hexacetonide, a synthetic glucocorticoid with a prominent anti-inflammatory and depot effect.

Key words:
Glucocorticoids, intra-articular, triamcinolone hexacetonide, rheumatoid arthritis, osteoarthritis, juvenile idiopathic arthritis


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