Factors affecting the efficacy of anti-TNF therapy in clinical practice: experience from the ATTRA national registry

Authors: K. Pavelka 1;  K. Chroust 2;  P. Němec 3
Authors‘ workplace: Revmatologický ústav a Revmatologická klinika 1. lékařské fakulty Univerzity Karlovy, Praha 1;  DSC Services, s. r. o., Tišnov 2;  II. interní klinika, Fakultní nemocnice u sv. Anny v Brně a Lékařská fakulta Masarykovy univerzity, Brno 3
Published in: Čes. Revmatol., 22, 2014, No. 4, p. 115-123.
Category: Original Papers


This study characterized response to the first trial of antitumor necrosis factor (TNF) drugs among rheumatoid arthritis (RA) patients in the Czech registry of biological therapy (ATTRA).

Materials & methods:
The study included all patients with disease activity scores (DAS28) >5.1, and a few with scores <5.1. Monoclonal antibodies were pooled and compared to etanercept for 1 year.

1945 patients were enrolled (518 etanercept, 1427 antibodies). From week 10–54, mean DAS28 was significantly lower with etanercept; and remission and low disease activity (LDA) rates were significantly higher. Etanercept was a significant predictor of remission.

Remission and LDA were more frequent with etanercept than with monoclonal antibodies..

Key words:
Rheumatoid arthritis, biological DMARDs, anti-TNF, etanercept, monoclonal antibodies


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Dermatology & STDs Paediatric rheumatology Rheumatology
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