Circulating Heat Shock Protein 90 (HSP90) in patients with rheumatoid arthritis and axial spondylarthritis

Czech version

Authors: L. Procházková ¹; J. Hulejová ²; P. Němec ¹; L. Šenolt ²
Authors‘ workplace: Revmatologie, II. interní klinika, FN u sv. Anny, Brno ¹; Revmatologický ústav a Revmatologická klinika, 1. LF UK, Praha ²
Published in: Čes. Revmatol., 21, 2013, No. 4, p. 164-169.
Category: Original Papers

Overview

Introduction:
Heat Shock Protein 90 (HSP90) is involved in the regulation of immunological and inflammatory responses, and its inhibition has been effectively used in the treatment of several animal models of autoimmune diseases. The role of HSP90 in rheumatic diseases is not precisely known. The aim of our study was to analyze the levels of HSP90 in the serum of patients with rheumatoid arthritis (RA) and compare them with those in patients with axial spondylarthritis (AxSpA) and in healthy volunteers and to evaluate the association of these findings with disease activity.

Methods:
HSP90 was analyzed in peripheral blood of 58 patients with RA, 68 patients with AxSpA and 30 healthy volunteers. Disease activity in patients with RA was assessed by the DAS28 score and in patients with AxSPA by BASDAI index. The concentration of serum C-reactive protein (CRP), autoantibodies (rheumatoid factors, anti-cyclic citrullinated peptides) and the presence of HLA-B27 were measured by standard methods.

Results:
Although the serum levels of HSP90 were not different between the groups of patients and healthy controls, patients with RA treated with anti-TNF therapy had significantly lower HSP90 serum levels compared with those without this treatment (6.03, 95% CI 3,77-12,00 vs. 8.46, 95% CI 4.26 to 18.78 ng/ml, p = 0.016). No relationship between serum HSP90 and clinical activity of both diseases was observed, however, in RA patients a positive correlation between serum HSP90 and CRP was found (p = 0.017). Circulating HSP90 had no relationship to autoantibody activity in RA.

Conclusion:
The results of this study highlight the potential significance of HSP90 in the regulation of the inflammatory process in rheumatoid arthritis.

Key words:
Rheumatoid arthritis, axial spondylarthritis, Heat Shock Proteins, disease activity

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Labels

Dermatology & STDs Paediatric rheumatology Rheumatology

Regulatory T cells as a tool in modulation of immune system

Polymyalgia rheumatica – is the biological therapy effective?

Article was published in

Czech Rheumatology

2013 Issue 4