Functional status and quality of life in patients with early and established rheumatoid arthritis


Authors: A. Čalfová 1;  Ž. Macejová 2;  I. Lazúrová 1
Authors‘ workplace: I. Interná klinika LF UPJŠ a UN LP, Košice, Slovensko 1;  III. Interná klinika LF UPJŠ a UN LP, Košice, Slovensko 2
Published in: Čes. Revmatol., 19, 2011, No. 4, p. 164-168.
Category: Original Papers

Overview

Recently a special methodological approach has been developed in order to assess individual’s state on the scale wellness – illness, based on the concept of quality of life. In relation to the medical context the term Health Related Quality of Life has been well established. This study has applied the Health Related Quality of Life approach on the population of rheumatoid arthritis patients.

Objective:
To explore and evaluate the Health Related Quality of Life in rheumatoid arthritis patients, with a special attention to the relationship of Health Related Quality of Life with functional status and disease activity in two separate rheumatoid arthritis groups with early and established form of rheumatoid arthritis respectively.

Patients and methods:
The study sample consisted of 102 early rheumatoid arthritis patients (mean disease duration 2,3 ± 1,3 years, 75% women, mean age 53,7 ± 12,4 years) and 130 established rheumatoid arthritis patients (mean disease duration 16,2 ± 4,2 years, 85% women, mean age 58,7 ± 9,9 years). All patients underwent a routine rheumatological examination including tenderness and swollen joint count and laboratory tests according to which disease activity DAS 28 was assessed. Functional status was assessed in every patient by Health Assessment Questionnaire Disability Index and quality of life was measured using Short Form 36-item Health Status Questionnaire.

Results:
Our analyses have generally shown that patients with established rheumatoid arthritis demonstrated worse functional status (1,39 ± 0,70) in comparison with recent rheumatoid arthritis patients (1,20 ± 0,75). However, no differences in individual Health Related Quality of Life domains were detected between these groups.

Conclusions:
Thus in spite of the functional deterioration during the progression of the disease in the long term this progression does not necessarily cause deterioration in subjective evaluation of health among rheumatoid arthritis patients. However, further longitudinal studies are required to confirm this finding.

Key words:
rheumatoid arthritis, functional disability, disease activity, quality of life, Health Related Quality of Life, HAQ-DI, RAND SF-36


Sources

1. World Health Organization Quality of Life group: Study protocol for the World Health Organization project to develop a quality of life assessment instrument (WHOQOL). Qual Life Res 1993; 2: 153-9.

2. Szilasiová A. a spol. Funkčné hodnotenie chorých s včasnou reumatoidnou artritídou. Rheumatologia 1997; 11: 205-11.

3. Bruce B, Fries JF. The Stanford Health Assessment Questionnaire: Dimensions and practical applications. Health Qual Life Outcomes 2003; 1: 20.

4. Guillemin F, Suurmeijer T, Krol B, Bombardier C, Briancon S, Doeglas D, et al. Functional disability in early rheumatoid arthritis: description and risk factors. J Rheumatol 1994; 6: 1051-5.

5. Scott DL, Smith C, Kingsley G. Joint damage and disability in rheumatoid arthritis: an updated systematic review. Clin Exp Rheumatol 2003; 5(Suppl 31): 20-7.

6. Wolfe F. A reappraisal of HAQ in rheumatoid arthritis. Arthritis Rheum 2000; 12: 2751-61.

7. Toussirot E. Predictive factors for disability as evaluated by the Health Assessment Questionnaire in Rheumatoid Arthritis: A Literature Review. Inflamm Allergy Drug Targets 2010; 1: 51-9.

8. West E, Jonsson SW. Health-related quality of life in rheumatoid arthritis in Northern Sweden: a comparison between patients with early RA, patients with medium-term disease and controls, using SF-36. Clin Rheumatol 2005; 2: 117-22.

9. Groarke A, Curtis R, Coughlan R, Gsel A. The role of perceived and actual disease status in adjustment to rheumatoid arthritis. Rheumatology (Oxford) 2004; 9: 1142-9.

10. Keystone EC, Kavanaugh AF, Sharp JT, Tannenbaum H, Hua Y, Teoh LS, et al. Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: a randomized, placebo-controlled, 52-week trial. Arthritis Rheum 2004; 5: 1400-11.

11. Rigby W, Ferraccioli G, Greenwald M, Zazueta-Montiel B, Fleischmann R, Wassenberg S, et al. Effect of rituximab on physical function and quality of life in patients with rheumatoid arthritis previously untreated with methotrexate. Arthritis Care Res 2011; 63: 711-20.

12. Macejová Ž. a spol. Zlepšenie kvality života pacientov s reumatoidnou artritídou po účinnej liečbe. Rheumatologia 2007; 21: 83-6.

Labels
Dermatology & STDs Paediatric rheumatology Rheumatology
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