Current view on etiopathogenesis of fibromyalgia

Authors: J. Tomš
Authors‘ workplace: Oddělení revmatologie a klinické farmakologie, 2. interní klinika Lékařské fakulty UK a Fakultní nemocnice Hradec Králové
Published in: Čes. Revmatol., 17, 2009, No. 3, p. 162-166.
Category: Overview Reports


Fibromyalgia (FM) is a syndrome that belongs to manifestations of extra-articular rheumatism, due to chronic wide-spread pain as its dominating symptom. Nevertheless, not even 100 years of intensive research have proved any specific changes in muscle tissue. On the contrary, growing evidence has recently indicated that FM is caused by abnormal regulation of pain transmission and processing. Central sensitization process with hyperexcitability of secondary neurons in the spinal cord and with decreased attenuating activity of descendent inhibitory system apparently play crucial role in it. Genetic factors and various trigger mechanisms can predispose individuals to application and clinical manifestation of these principles. In addition, modulation of pain perception, due to emotional and possibly psychopathological factors, may contribute to aforementioned mechanisms.

Key words:
fibromyalgia, etiopathogenesis of pain, central sensitization


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