Interleukin 6 in rheumatic diseases

Authors: H. Mann
Authors‘ workplace: Revmatologický ústav, Praha
Published in: Čes. Revmatol., 17, 2009, No. 1, p. 30-35.
Category: Overview Reports


Interleukin 6 is a pleiotropic cytokine, which has an impact on various cell lines through a unique mechanism of signal transmission and significantly participates in the regulation of immune response. IL-6 has an important role in the etiopathogenesis of inflammatory rheumatic diseases. The IL-6 blocking via tocilizumab – a humanized monoclonal antibody against IL-6R – has proved its efficacy in the treatment of rheumatoid arthritis and juvenile idiopathic arthritis with systemic onset.

Key words:
Interleukin 6, signal transmission, tocilizumab, rheumatoid arthritis, SOJIA


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Dermatology & STDs Paediatric rheumatology Rheumatology
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