Serum levels of ICAM-1, VCAM-1 andgelatinase A and B as possible predictive markers of rheumatoid arthritis

Authors: J. Šťovíčková;  S. Macháček;  J. Gatterová
Authors‘ workplace: Revmatologický ústav, Praha
Published in: Čes. Revmatol., , 2003, No. 3, p. 138-145.


Rheumatoid arthritis is a potentially severe and disability-related disease and thereforegreat effort is exerted to find reliable predictive markers of the disease. Recently the interaction ofadhesion molecules ICAM-1 or VCAM-1 on the surface of mesenchymal cells with T-cell integrins wasshown to activate expression of gelatinases. The extracellular matrix of affected joints is degradedby gelatinases. Methods. Serum levels of ICAM-1, VCAM-1, gelatinase A and B were measured in 60patients with early rheumatoid arthritis and correlated with CRP values, DAS scores, and withradiographic impairment assessed by Larsen score. The levels of sICAM-1, sVCAM-1, both of thegelatinases and CRP were evaluated every six months and DAS score value and Larsen score everytwelve months over a period of two years of follow up. Results. The sICAM-1 levels correlated withsVCAM-1 (0.3147

Key words:
rheumatoid arthritis, adhesion molecules, gelatinases

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Dermatology & STDs Paediatric rheumatology Rheumatology
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account