Early detection of nervous system dysfunctionin patients with systemic lupus erythematosus by evoked potentials – a case report

Authors: I. Štětkářová 1;  M. Veselá 2;  O. Kryštůfková 2
Authors‘ workplace: Neurologické oddělení Nemocnice Na Homolce, Praha2Neurologická ambulance, Revmatologický ústav, Praha 1
Published in: Čes. Revmatol., , 2003, No. 2, p. 99-103.


In patients with verified diagnosis of systemic lupus erythematosus (SLE)without any topical signsof central nervous system impairment, the visual, brainstem auditory, somatosensory, and motorevoked potentials were performed. Small hyperintensive lesions supra- and infratentorial in whitematter were detected by MRI.We found and abnormal median cortical response and absence and/orshortening of silent period after transcranial magnetic stimulationwhich we interpreted as a slightdysfunction of supraspinal and/or cortical somatosensory generator of inhibitory interneurons inthe motor cortex. Multimodal evoked potentials could become a useful electrophysiological methodto detect subclinical central nervous impairment in SLE.

Key words:
vasculitis, systemic lupus erythematosus, evoked potentials, somatosensory evokedpotentials, motor evoked potentials, lupus cephalgia

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Dermatology & STDs Paediatric rheumatology Rheumatology
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