Psychosomatic aspects and antipsychotics medication in ethiopathogenesis of endometrial carcinoma

Authors: M. Kudela 1,2;  L. Hansmanová 1
Authors‘ workplace: Porodnicko-gynekologická klinika FN a LF UP, Olomouc, přednosta prof. MUDr R. Pilka, Ph. D. 1;  Ústav zdravotnických věd, FHS UTB Zlín, ředitelka Mgr. Z. Dorková, Ph. D 2
Published in: Čes. Gynek.2014, 79, č. 5 s. 378-381


To assess possible role of psychosomatic aspects and antipsychotic medical treatment in ethio-pathogenesis of endometrial cancer.

Prospective study and revue of literature.

Department of Obstetrics and Gynecology, Faculty of Medicine and Dentistry, University Hospital, Olomouc; Department of Health Care Science, Faculty of Humanities, Tomas Bata University in Zlín.

A case-control study was conducted on 40 patients who underwent surgical treatment for histopathologicly confirmed diagnosis of endometrial cancer. Patients on admition were examined by means of the standardised Minnesota personality inventory MMPI-2. Antipsychotic medical treatment in patients history was recorded.

Our study confirmed signinicantly increas in the scale of depression, anxiety, psychastenia, social introversion, low self-respect, A-type behaviour and hostility. On the other hand there were no changes in the scale of hysteria and lie. A possible role of antipsychotics is discussed.

endometrial carcinoma, psychosomatic aspects, antipsychotics medication


1. Pereira, DB., Cannes, T., Dodd, SM., et al. Life stress, negative mood status and heat shock protein 70 in endometrial cancer. Brain Behav Immun, 2010, 24, p. 210–214.

2. Dexeus, S., Barri, PN. Hyperprolactinemia: An inductor of neoplastic changes in endometrium ? A report of two cases. Gynecol Endocrinol, 1998, 12, p. 273–275.

3. Hansmanová, L. Psychologické aspekty problematiky gynekologické onkologie. Doktorská disertační práce, 2006.

4. Jabbour, HN., Critchley, HOD, Boddy, SC. Expressinon of functional prolactin receptors in nonpregnant human endometrium: Janus kinase-2, signal transducer and activator of trascription-1 (STAT 1), and STAT 5 proteins are phosphorylated after stimulation with prolactin. J Clin Endocrinol Metab. 1998, 83, p. 2545–2553.

5. Koji ,Y., Hideo, M., Kasuyoshi, S., Souei, S. A case-control study of endometrial cancer after antipsychotics exposure in premenopausal women. Oncology, 2003, 64, p. 118–123.

6. La Bella, FS, Brandes, LJ. Enhancement of tumor growth by drugs with some common molecular actions. Mol Carcinog, 1996, 16, p. 68–76.

7. Nielsen, NR., Standberg-Larsen, K., Gronbaek, M., et al. Self-reported stress and risk of endometrial cancer: a prospective cohort study. Psychosom Med, 2007, 69, p. 383–389.

8. Pennix, BW., Guralnik, JM., Pahor, M., et al. Chronically depressed mood and cancer risk in older persons. J Natl Cancer Inst, 1998, 90, p. 1888–1893.

9. Ristic, PI., Ory, SJ., Lurain, JR. Endometrial adenocarcinoma associated with drug-induced hyperprolactinemia. Obstet. Gynecol, 1986, 67, p. 86–88.

10. Schraub, S., Snacho-Garnier, H., Velten, M. Should psychological events be considered cancer risk factors? Rev Epidemiol Sante Publique, 2009, 57, p. 113–123.

11. Tinelli, A., Vegara, D., Martigango, R., et al. Hormonal carcinogenesis and socio-biological development factors in endometrial cancer : a clinical review. Acta Obstet Gynecol Scand, 2008, 87, p. 1113.

Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

Article was published in

Czech Gynaecology

Issue 5

2014 Issue 5

Most read in this issue

This topic is also in:

Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account