Genetic aspects of pelvic floor defects and stress urinary incontinence in women

Authors: P. Lukáč 1;  K. Biringer 1;  J. Siváková 1;  M. Hrtánková 1;  Z. Lasabová 2;  J. Danko 1
Authors‘ workplace: Gynekologicko-pôrodnícka klinika JLF UK a UNM, Martin, Slovenská republika, prednosta prof. MUDr. J. Danko, CSc. 1;  Ústav molekulovej biológie JLF UK a UNM, Martin, Slovenská republika, vedúca doc. RNDr. Z. Lasabová, PhD. 2
Published in: Čes. Gynek.2014, 79, č. 5 s. 382-387


An overwiev of the genetic aspects of pelvic floor defects and stress urinary incontinence in women.

A review article.

Department of Gynecology and Obstetrics, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovak Republic.

An analysis of the literature using database search engines PubMed, BLAST and Ensembl in field of POP and SUI.

Pelvic organ prolapse (POP) and stress urinary incontinence (SUI) affect a large number of women and often requires surgical correction. Moreover, these diseases are not only individual health but also social and economic burden on patients and society. It is possible to prevent or at least timely intervene these pathologies by screening of risk patients. The incidence of these disorders leads to find possible genetic factors. In ethiopathogenetic studies of pelvic floor defects and stress urinary incontinence it is looking for genes associated with these diseases and optimization of molecular biology methods is necessary to determine the possible gene mutations or polymorphism site. Selection of relevant genetic factors tend to clarify the pathomechanism of SUI and POP that can greatly affect their current diagnostics and therapeutics.

prolapse, stress urinary incontinence, polymorphism, gene expression


1. Cartailler, JP., Khoshnoodi, J., Alvares, K., et al. Molecular recognition in the assembly of collagens: Terminal noncollagenous domains are key recognition modules in the formation of triple-helical protomers. J Biol. Chem, 2006, 281(50), p. 38117–38121.

2. Čihak, R., et al. Anatomie. 2. vyd. Praha: Grada, 2011, s. 470.

3. Daniels, JT., Cambrey, AD., Occleston, NL., et al. Matrix metalloproteinase inhibition modulates fibroblasts – mediated matrix concentration and collagen production in vitro. Invest Ophthalmol Vis Sci, 2003, 44(3), p. 1104–1110.

4. Ferrari, MM., Rossi, G., Biondi, ML., et al. Type I collagen and matrix metalloproteinase 1, 3 and 9 gene polymorphisms in the predisposition to pelvic organ prolapse. Arch Gynecol Obstet, 2012, 285(6), p. 1581–1586.

5. Chen, C., Hill, LD., Schubert, CM., et al. Is laminin gamma-1 a candidate gene for advanced pelvic organ prolapse. Am J Gynaecol Obstet, 2010, 202(5), p. 505–510.

6. Chen, HY., Chung, YW., Lin, WY., et al. Collagen type 3 alpha 1 polymorphism and risk of pelvic organ prolapse. Am J Obstet Gynecol, 2008, 103(5), p. 55–58.

7. Kim, BC., Kim, W.Y., Park, D., et al. SNP@Promoter: a database of human SNPs (Single Nucleotide Polymorphisms) within the putative promoter regions. BMC BioInformation Center, 2008, 9, S2, p. 1186–1192 .

8. Latchman, DS. Transcription factors: an overview. Int J Biochem Cell Biology, 1997, ISSN 1357–2725.

9. Li, B., Zhang, QF., Lin, XY., et al. Expression and significance of elastin and fibulin-5 in anterior vaginal tissue of women with pelvic organ prolapse. Zhonghua Fu Chan Ke Za Zhi, 2009, 44(7), p. 514–517.

10. Muiznieks, L., Weiss, A., Keeley, F. Structural disorder and dynamics of elastin. Biochem Cell Biol, 2010.

11. Nimwegen, E. Scaling laws in the functional content of genomes. Trends Genet, 2003.

12. Nygaard, I., Turvey, C., Burns, TL., et al. Urinary incontinence and depression in middle-aged United States women. Obstet Gynecol, 2003, 101(1), p. 149–156.

13. Petr, J. Odhalen gen pro „křehké kosti“. (online) 10/2006 (cit . 2014.2.25

14. Silbernagel, S., Lang, F. Atlas patofyziologie člověka. 1. vyd. Praha: Grada Publishing, 2001, s. 404.

15. Söderberg, MW., Byström, B., Kalamajski, S., et al. Gene expressions of small leucine – rich repeat proteoglycans and fibulin-5 are decreased in pelvic organ prolapse. Mol Hum Reprod, 2009, 15(4), p. 251–257.

16. Wang, L., Han, LY., Li, HL. Etiological study of pelvic organ prolapse and stress urinary incontinence with collagen status and metabolism. Zhonghua Yi Xue Za Zh, 2013, 93(7), p. 500–503.

17. Wu, JM., Visco, AG., Grass, EA., et al. Matrix metalloproteinase-9 genetic polymorphisms and the risk for advanced pelvic organprolapse. Obstet Gynec, 2012, 120(3), p. 587–593.

18. Zhang, SQ., Zhang, LL., Yu, H. Expression of elastin, lysyl oxidase and elafin in the cardinal ligament of women with pelvic organ prolapse. Zhonghua Fu Chan Ke Za Zhi, 2008, 43(9), p. 675–679.

Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

Article was published in

Czech Gynaecology

Issue 5

2014 Issue 5

Most read in this issue

This topic is also in:

Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account