Process of women’s reproductive ageing – causes, evaluation and possible clinical usage

Authors: M. Huser;  I. Crha;  J. Žáková;  P. Ventruba
Authors‘ workplace: Gynekologicko-porodnická klinika LF MU a FN, Brno, přednosta prof. MUDr. P. Ventuba, DrSc.
Published in: Čes. Gynek.2010, 75, č. 4 s. 353-358


Women’s fertility steeply decreases with increasing age, but the intensity of the decrease is individually significantly variable. The main cause of fertility drop is rapid decrease of ovarian follicle count. Deletion of ovarian follicles happens mainly by the mechanism of cell apoptosis. Nevertheless in the whole process participates also others exogenous and endogenous factors. At present new major steps in the complex ovarian ageing process has been identified and some innovative therapeutic strategies have been suggested to influence this process. At the end this paper evaluates currently available markers of ovarian reserve and its abilities to be used in routine clinical practice.

Key words:
fertility, menopause, ovary, ovarian follicle, ovarian reserve, reproductive age, apoptosis.


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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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