Hematologic malignancies in pregnancy


Authors: R. Doubek 1;  D. Petrovová 1;  J. Kalvodová 1;  M. Doubek 2
Authors‘ workplace: Gynekologicko-porodnická klinika LF MU a FN, Brno, přednosta prof. MUDr. P. Ventruba, DrSc. 1;  Interní hematoonkologická klinika LF MU a FN, Brno, přednosta prof. MUDr. J. Vorlíček, CSc. 2
Published in: Čes. Gynek.2009, 74, č. 2 s. 138-143
Category: Original Article

Overview

Objective:
To summarize available data concerning hematologic malignancies in pregnancy.

Desine:
Review article.

Setting:
Department of Obstetrics and Gynekology, Fakulty of Medicine, Masaryk University and University Hospital Brno.

Methods:
Compilation of published data from scientific literature.

Conclusions:
Cancer complicating pregnancy is a rare coexistence. The incidence is approximately 1 in 1,000 pregnancies. The most frequent hematologic malignant tumor is Hodgkin’s lymphoma, leukemia is less frequent and myeloproliferative diseases complicating pregnancy are sporadic coexistence. Symptoms of these deseases are often nonspecific and disguised in pregnancy, then the diagnosis can be late. It is imperative that a multidisciplinary team involving hematooncologist and obstetrician (pediatric specialist) care for patient with hematologic malignancies. Cleary, every patient have to know whole prognosis and all risk factors of treatment. Optimum timing of delivery is after 36th week of pregnancy (when chemotherapy is ended more than two weeks ago). We prefer vaginal delivery to caesarean section.

Key words:
leukemia, lymphoma, myeloproliferative diseases, pregnancy, treatment.


Sources

1. Cardonick, E., Iacobucci, A. Use of chemotherapy during human pregnancy. Lancet Oncol, 2004, 5, p. 283-291.

2. Dildy, GA., Moise, KJ., Carpenter, RJ., et al. Maternal malignance metastatic to the products of conception: a review. Obstet Gynecol Surv, 1989, 44, p. 535-540.

3. Doubek, M., Brychtova, Y., Doubek, R., et al. Anagrelide therapy in pregnancy: repost of a case of essential thrombocythemia. Ann Hematol, 2004, 83, p. 726-727.

4. Griesshammer, M., Struve, S., Harrison, CM. Essential thrombocythemia/polycythemia vera and pregnancy: the need for an observational study in Europe. Semin Tromb Hemost, 2006, 32, p. 422-429.

5. Hurley, TJ., McKinnell, JV., Irani, MS. Hematologic malignancies in pregnancy. Obstet Gynecol Clin N Am, 2005, 32, p. 595-614.

6. Hurley, TJ., Montgomery, R., Waldron, J., et al. Fatal course of malignant non-Hodgkin’s lymphoma of T-cell type during pregnancy with metastasis to the fetus. J Matern Fetal Med, 1994, 3, p. 69-74.

7. Kaiser, HE., Nawab, E., Nasir, A., et al. Neoplasms during the progression of pregnancy. In Vivo, 2000, 14, 1, p. 277-285.

8. Kantarjian, HM., Talpaz, M., Gildes, F., et al. New insights into the pathopysiology of chronic myeloid leukemia and imatinib resistence. Ann Intern Med, 2003, 145, p. 913-923.

9. Kopeć, I., Debski, R., Samsel, M., et al. Hairy cell leukemia in pregnancy. Ginekol Pol 2005, 76, p. 898-901.

10. Maruko, K., Maeda, T., Kamitomo, M., et al. Transplacental transmission of maternal B-cell lymphoma. Am J Obstet Gynecol, 2004, 191, p. 380-381.

11. Pavlidis, NA. Coexistence of pregnancy and malignancy. Oncologist, 2002, 7, p. 279-287.

12. Peleg, D., Ben-Ami, M. Lymphoma and leukemia complicating pregnancy. Obstet Gynecol Clin North Am, 1998, 25, p. 365-383.

13. Pereg, D., Koren, G., Lishner, M. The treatment of Hodgkin’s and non-Hodgkin’s lymphoma in pregnancy. Haematologica, 2007, 92, p. 1230-1237.

14. Pohlman, B., Macklis, RM. Lymphoma and pregnancy. Semin Oncol, 2000, 27, p. 657-666.

15. Riccioni, R., Galimberti, S., Petrini, M. Hairy cell leukemia. Curr Treat Options Oncol, 2007, 8, p. 129-134.

16. Shaphira, T., Pereg, D., Lishner, M. How I treat acute and chronic leukemia in pregnancy. Blood Rev, 2008, 22, p. 247-259.

17. Stiles, GM., Stanco, LM., Saven, A., et al. Splenectomy for hairy cell leukemia in pregnancy. J Perinatol, 1998, 18, p. 200-201.

18. Yucebilgin, MS., Cagirgan, S., Donmez, A., et al. Acute myeloblastic leukemia in pregnancy: a case report and review of the literature. Eur J Gynaecol Oncol, 2004, 25, 1, p. 126-128.

Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

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Czech Gynaecology

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2009 Issue 2

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