R. Pilka; P. Dzvinčuk; M. Kudela
Gynekologicko-porodnická klinika LF UP a FN Olomouc, přednosta prof. M. Kudela, CSc.
Čes. Gynek.2003, , č. 6 s. 427-431
Objective: To summarise recent knowledge about lymphangiogenesis, markers of the lymphaticendothelium and their importance to the tumor dissemination.Design: A literature review.Setting: Department of Gynecology and Obstetrics, Medical Faculty, Palacký University, UniversityHospital, Olomouc.Abstracts: Clinicopathological data suggest that the lymphatics are an initial route for the spreadof solid tumors. Detection of sentinel lymph nodes by biopsy provides signiﬁ cant information forstaging and designing therapeutic regimens. The role of angiogenesis (formation of new bloodvessels) in facilitating the growth of tumors has been well established, but the presence of lymphaticvessels and the relevance of lymphangiogenesis (formation of new lymphatics) to tumorspread are less clear. Growth factors involved in lymphangiogenesis during embryogenesis havebeen recently identiﬁ ed and showed to be able to induce formation of intratumoral lymphaticsand thus facilitate metastatic spread to lymph nodes. The development of approaches to blocktumor lymphangiogenesis and treat lymphedema would beneﬁ t from the availability of markersspeciﬁ c for lymphatic endothelium.