Screening for Factor V Leiden Mutation (FVL)in Users of Combined Oral Contraceptives (COC)or Hormone Replacement Therapy (HRT)

Czech version

Authors: D. Cibula ¹; V. Unzeitig ²; J. Živný ¹
Authors‘ workplace: Gynekologicko-porodnická klinika 1. LF UK a VFN v Praze, přednosta prof. MUDr. J. Živný, DrSc. 2Gynekologicko-porodnická klinika, LF MU a FN Brno, přednosta prof. MUDr. P. Ventruba, DrSc. ¹
Published in: Ceska Gynekol 2003; (3): 167-174
Category:

Overview

Objective:
Analysis of the issue of screening for Factor V Leiden mutation (FVL) in users of combinedoral contraceptives (COC) or hormone replacement therapy (HRT).Design: Review article.Setting: Department of Obstetrics and Gynecology, Charles University and GeneralFaculty Hospital,Prague.Methods: Review of published facts, analysis of possibilities to screen all users or to test risk groupsin the current situation in the Czech Republic.Conclusion: 1) Screening for FVL in allCOCorHRTusers is not recommended mostly for economicalreasons. 2) Testing for FVL is indicated in women with a positive family history of thromboembolicdisease and in obese women, if they consider COC or HRT despite our recommendation or in casethere is a medical indication. 3) Deep venous thrombosis or pulmonary embolism are absolutecontraindications of COC or HRT regardless of the presence of FVL.

Key words:
combined oral contraceptives, hormone replacement therapy, thromboembolic disease,Factor V Leiden mutation, hereditary thrombophilias

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