Advanced Oxidation Protein Products in Pregnancy
M. Kalousová 1,2; L. Fialová 1; T. Zima 2; I. M. Malbohan 1,2; L. Krofta 3; J. Soukupová 2; L. Mikulíková 2; S. Štípek 1
Ústav lékařské biochemie 1. LF UK Praha, přednosta prof. MUDr. S. Štípek, DrSc. 2Ústav klinické biochemie 1. LF UK a VFN Praha, přednosta prof. MUDr. T. Zima. DrSc. 3Ústav pro péči o matku a dítě Praha, ředitel doc. MUDr. J. Feyereisl, CSc.
Ceska Gynekol 2002; (4): 194-197
Pregnancy and mainly its complications are associated with increased oxidative stress.Advanced oxidation protein products (AOPP) can serve as one of its markers.Setting: First Institute of Medical Chemistry and Biochemistry and Institute for Clinical Biochemistry,First Medical Faculty, Charles University; Institute for Care of Mother and Child, Prague.Methods: Together with parameters of prenatal screening, AOPP were measured in the serum of23 pregnant women in the 2nd trimester of pregnancy. A group of healthy blood donors – womenand men was used for comparison. AOPP were determined spectrophotometrically according toWitko-Sarsat (absorbance at 340 nm) and are expressed in chloramin units (mmol/l).Results: Serum AOPP concentrations in pregnant women are significantly higher in comparisonwith blood donors – women (85.90±18.70 mmol/l vs 57.34±16.31 mmol/l, P
oxidative stress, pregnancy, advanced oxidation protein products
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Gynaecology and obstetrics