Authors: R. Nenutil 1; Matěj Anton 2; S. Uldrijan 4; D. Valík 5; B. Ptáčková 3; B. Vojtěšek 4 Authors‘ workplace: Department of Pathology, Faculty Woman’s Hospital Brno, Obilní trh 11, 656 17 Brno, Czech Republic 2 2 nd Dept. Obstet. Gynaecol., Faculty Hospital, Jihlavská 20, 639 01 Brno-Bohunice, Czech Republic 3 Department of Gynaecology, Masaryk Memorial Cancer In 1 Published in: Ceska Gynekol 2000; (5): 287-291 Category:
Objectives: The present study examines expression of p53 protein and its association with clinicalparameters in locally advanced squamous cell carcinoma of the uterine cervix.Design: Retrospective clinical and pathological study.Setting: Department of Pathology, Faculty Women’s Hospital Brno, Czech Republic, Departmentof Cellular and Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Repu-blic.Methods: The expression of p53 protein was immunohistochemically explored in 48 clinicallyadvanced squamous cell cervical carcinomas.Results: Prior to radiotherapy treatment, p53 was detected in 41 (87.3%) cases but only 21 (43,5%)cases exceeded 3% of positive nuclei. One case showed a diffuse staining pattern. The patientswith p53 staining in more than 3% of nuclei had more favourable prognosis with better responseto radiotherapy when compared to negative and/or weakly positive cases. The occurrence ofdistant metastases did not differ between these groups.Conclusion: This data support the findings that mutation of p53 is usually not involved in thegenesis of cervical squamous cell malignancy. A subset of cervical cancer may exist with elevatedlevel of p53 protein, which retain the p53 tumour supressor function but exhibit genotoxic stress.These tumours may respond better to radiotherapy.
Key words: p53 protein, squamous cell carcinoma, uterine cervix, prognosis
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