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3D FACIAL MORPHOMETRY IN PATIENS WITH OCULO-AURICULO-VERTEBRAL SPECTRUM


Authors: P. Švihlíková Poláčková 1,3;  V. Moslerová 2;  M. Koťová 1,3
Authors‘ workplace: Oddělení ortodoncie a rozštěpových vad, Stomatologická klinika, 3. lékařská fakulta Univerzity Karlovy a Fakultní nemocnice Královské Vinohrady, Praha 1;  Ústav biologie a lékařské genetiky, 2. lékařská fakulta Univerzity Karlovy a Fakultní nemocnice Motol, Praha 2;  Klinika zubního lékařství, Lékařská fakulta Univerzity Palackého a Fakultní nemocnice, Olomouc 3
Published in: Česká stomatologie / Praktické zubní lékařství, ročník 119, 2019, 2, s. 48-56
Category: Original articles

Overview

Introduction and aim: Oculo-auriculo-vertebral spectrum (OAVS) is a congenital complex of extremely variable phenotypes. Typically, unilaterally affected structuresare facial structures developing from the first and second branchial arches and first pharyngeal pouch and first branchial cleft and the basis of temporal bone.

The aim is to introduce the clinical conditions of the disease whose facial asymmetry is accompanied by a number of functional disorders. Moreover, it presents non-invasive 3D morphometry, that enables evaluation of the morphological deviation of the affected area.

Methods: An accurate geometric 3D image of the patient's face was created by the optical method – stereophotogrammetry in six patients (age from 6 to 15; 5 , 1 ) with OAVS. Using the construction of dense correspondence mapping by CPD-DCA (coherent point drift – dense correspondence analysis) method between facial meshes, model registration were performed. A perfectly symmetrical face was constructed for each patient. The differences between the constructed symmetrical face and the real patient's face were shown using a color map. The individual asymmetry thus displayed was quantitatively processed and analyzed over a period of nine to 23 months.

Results: Only minor differences in facial asymmetry of OAVS patients have been demonstrated, suggesting an insignificant dynamics in the development of facial malformations in patients with this disease. We did not find a dependence between face relief changes and patient age during the reference period. There was also no correlation between the severity of the defect and the development of asymmetry.

Conclusion: Significant worsening of facial morphology in growing OAVS patients has not been confirmed as supposed. That allows satisfactory compensation of defects by early orthodontic treatment. Non-invasive 3D morphometric facial scanning is an optimal method for monitoring the development of facial asymmetries.

Keywords:

oculo-auriculo-vertebral spectrum – facial asymmetry – 3D morphometry


Sources

1. Gorlin RJ, Jue KL, Jacobsen U, Goldschmidt E. Oculoauriculovertebral dysplasia. J Pediatr. 1963; 63(5): 991–999.

2. Hennekam RC, Allanson JE, Krantz ID. Gorlin's syndromes of the head and neck. 5. vydání. New York: Oxford University Press; 2010: 879–884.

3. Thomson A. A description of congenital malformation of the auricle and external meatus of both sides in three persons, with experiments on the state of hearing in them, and remarks on the mode of hearing by conduction through the hard parts of the head in general. P Roy Soc Edinb A. 1845; 1: 443–446. https://doi.org/10.1017/S0370164600039778

4. Kokavec R. Goldenhar syndrome with various clinical manifestations. Cleft Palate-Craniofacial J. 2006; 43(5): 628–634.

5. Cousley RRJ, Calvert ML. Current concepts in the understanding and management of hemifacial microsomia. Br J Plast Surg. 1997; 50(7): 536–551.

6. Grabb WC. The first and second branchial arch syndrome. Plast Reconstr Surg. 1965; 36(5): 485–508.

7. Cohen JM, Rollnick BR, Kaye CI. Oculoauriculovertebral spectrum: an updated critique. Cleft palate J. 1989; 26(4): 276–286.

8. Caldarelli DD, Hutchinson JJ, Pruzansky S, Valvassori GE. A comparison of microtia and temporal bone anomalies in hemifacial microsomia and mandibulofacial dysostosis. Cleft Palate J. 1980; 17(2): 103–110.

9. Kitai N, Murakami S, Takashima M, Furukawa S, Kreiborg S, Takada K. Evaluation of temporomandibular joint in patients with hemifacial microsomia. Cleft Palate-Craniofacial J. 2004; 41(2): 157–162.

10. Rollnick BR, Kaye CI, Nagatoshi K, Hauck W, Martin AO, Reynolds JF. Oculoauriculovertebral dysplasia and variants: phenotypic characteristics of 294 patients. Am J Med Genet. 1987; 26(2): 361–375.

11. Bennun RD, Mulliken JB, Kaban LB, Murray JE. Microtia: a microform of hemifacial microsomia. Plast Reconstr Surg. 1985; 76(6): 859–865.

12. Converse JM, Coccaro PJ, Becker M, Wood-Smith D. On hemifacial microsomia: the first and second branchial arch syndrome. Plast Reconstr Surg. 1973; 51(3): 268–279.

13. Sleifer P, de Souza Gorsky N, Goetz, TB, Rosa RFM, Zen PRG. Audiological findings in patients with oculo-auriculo-vertebral spectrum. Int Arch Otorhinolaryngol. 2015; 19(01): 005–009.

14. Birgfeld CB, Heike C. Craniofacial microsomia. Semin Plast Surg. 2012; 26(2): 91–104.

15. Shokeir MH. The Goldenhar syndrome: a natural history. Birth Defects Orig Artic Ser. 1976; 13(3C): 67–83.

16. Takashima M, Kitai N, Murakami S, Furukawa S, Kreiborg S, Takada K. Volume and shape of masticatory muscles in patients with hemifacial microsomia. Cleft Palate-Craniofacial J. 2003; 40(1): 6–12.

17. Barisic I, Odak L, Loane M, Garne E, Wellesley D, Calzolari E, Dolk H, Addor AM, Arriola L, Bergman J, Bianca S, Doray B, Khoshnood B, Klungsoyr K, McDonnell B, Pierini A, Rankin J, Rissmann A, Rounding C, Queisser-Luft A, Scarano G, Tucker D. Prevalence, prenatal diagnosis and clinical features of oculo-auriculo-vertebral spectrum: a registry-based study in Europe. Eur J Hum Genet. 2014; 22(8): 1026–1033.

18. Richieri-Costa A, Ribeiro LA. Macrostomia, preauricular tags, and external ophthalmoplegia: A new autosomal dominant syndrome within the oculoauriculovertebral spectrum? Cleft Palate-Craniofacial J. 2006; 43(4): 429–434.

19. Horgan JE, Padwa BL, Labrie RA, Mulliken JB. OMENS-Plus: analysis of craniofacial and extracraniofacial anomalies in hemifacial microsomia. Cleft Palate-Craniofacial J. 1995; 32(5): 405–412.

20. Lane C, Harrell Jr W. Completing the 3-dimensional picture. Am J Orthod Dentofac Orthop. 2008; 133(4): 612–620.

21. Krimmel M, Kluba S, Bacher M, Dietz K, Reinert S. Digital surface photogrammetry for anthropometric analysis of the cleft infant face. Cleft Palate-Craniofacial J. 2006; 43(3): 350–355.

22. Kearns GJ, Padwa BL, Mulliken JB, Kaban LB. Progression of facial asymmetry in hemifacial microsomia. Plast Reconstr Surg. 2000; 105(2): 492–498.

23. Shibazaki-Yorozuya R, Yamada A, Nagata S, Ueda K, Miller A J, Maki K. Three-dimensional longitudinal changes in craniofacial growth in untreated hemifacial microsomia patients with cone-beam computed tomography. Am J Orthod Dentofac Orthop. 2014; 145(5): 579–594.

24. Solem RC, Ruellas A, Miller A, Kelly K, Ricks-Oddie JL, Cevidanes L. Congenital and acquired mandibular asymmetry: Mapping growth and remodeling in 3 dimensions. Am J Orthod Dentofac Orthop. 2016; 150(2): 238–251.

25. Meazzini MC, Mazzoleni F, Bozzetti A, Brusati R. Comparison of mandibular vertical growth in hemifacial microsomia patients treated with early distraction or not treated: follow up till the completion of growth. J Cranio Maxill Surg. 2012; 40(2): 105–111.

26. Ongkosuwito EM, van Vooren J, van Neck JW, Wattel E, Wolvius EB, van Adrichem LN, Kuijpers-Jagtman AM. Changes of mandibular ramal height, during growth in unilateral hemifacial microsomia patients and unaffected controls. J Cranio Maxill Surg. 2013; 41(2): 92–97.

27. Polley JW, Figueroa AA, Liou EJW, Cohen M. Longitudinal analysis of mandibular asymmetry in hemifacial microsomia. Plast Reconstr Surg. 1997; 99: 328–339.

Labels
Maxillofacial surgery Orthodontics Dental medicine
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