Authors: J. Hons Authors‘ workplace: Psychiatrická klinika LF UK a FN Hradec Králové, přednosta prof. MUDr. J. Libiger, CSc. Published in: Čes. a slov. Psychiat., , 2004, No. 4, pp. 220-228. Category:
The dysfunction of the neurons containing excitatory amino acids is present in a wide range ofneurodegenerative disorders. Schizophrenia may also result from a dysfunction of excitatoryamino acid neurotransmission. There are two glutamatergic hypotheses of schizophrenia.Glutamate hypofunction hypothesis supposes hypofunction of cerebral glutamatergic neuronsin schizophrenia. The most signifi cant consequence of the hypothesis is a possible use of drugsenhancing glutamatergic neurotransmission in the treatment of schizophrenic symptoms.Glutamate hyperfunction hypothesis was also proposed. It suggests a possible effect of glutamaterelease-inhibiting drugs in schizophrenia.
Key words: glutamate, schizophrenia, glutamatergic hypothesis, NMDA receptor.
Don‘t have an account? Create new account
Enter the email address that you registered with. We will send you instructions on how to set a new password.
