The Role of Glutamatergic Neurotransmission in Pathophysiology of Schizophrenia
Psychiatrická klinika LF UK a FN Hradec Králové, přednosta prof. MUDr. J. Libiger, CSc.
Čes. a slov. Psychiat., , 2004, No. 4, pp. 220-228.
The dysfunction of the neurons containing excitatory amino acids is present in a wide range ofneurodegenerative disorders. Schizophrenia may also result from a dysfunction of excitatoryamino acid neurotransmission. There are two glutamatergic hypotheses of schizophrenia.Glutamate hypofunction hypothesis supposes hypofunction of cerebral glutamatergic neuronsin schizophrenia. The most signifi cant consequence of the hypothesis is a possible use of drugsenhancing glutamatergic neurotransmission in the treatment of schizophrenic symptoms.Glutamate hyperfunction hypothesis was also proposed. It suggests a possible effect of glutamaterelease-inhibiting drugs in schizophrenia.
glutamate, schizophrenia, glutamatergic hypothesis, NMDA receptor.
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