The Role of Glutamatergic Neurotransmission in Pathophysiology of Schizophrenia


Authors: J. Hons
Authors‘ workplace: Psychiatrická klinika LF UK a FN Hradec Králové, přednosta prof. MUDr. J. Libiger, CSc.
Published in: Čes. a slov. Psychiat., , 2004, No. 4, pp. 220-228.
Category:

Overview

The dysfunction of the neurons containing excitatory amino acids is present in a wide range ofneurodegenerative disorders. Schizophrenia may also result from a dysfunction of excitatoryamino acid neurotransmission. There are two glutamatergic hypotheses of schizophrenia.Glutamate hypofunction hypothesis supposes hypofunction of cerebral glutamatergic neuronsin schizophrenia. The most signifi cant consequence of the hypothesis is a possible use of drugsenhancing glutamatergic neurotransmission in the treatment of schizophrenic symptoms.Glutamate hyperfunction hypothesis was also proposed. It suggests a possible effect of glutamaterelease-inhibiting drugs in schizophrenia.

Key words:
glutamate, schizophrenia, glutamatergic hypothesis, NMDA receptor.

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Labels
Addictology Paediatric psychiatry Psychiatry
Login
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account