Orodispersable dosage forms and technologies used in their production


Authors: J. Gajdziok 1;  M. Rabišková 1
Authors‘ workplace: Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav technologie léků 1
Published in: Čes. slov. Farm., 2010; 59, 251-255
Category: Review Articles

Overview

Modern orodispersable dosage forms come to the forefront of the interest of patients and pharmaceutical companies for its undisputed advantages, namely application comfort without the necessity of drinking, fast onset of action, good bioavailability of the active substance, dosage accuracy, reduction of side effects, and increased safety of the therapy. The dominant formulations across the group have remained orally dispersible tablets, supplemented more recently by dispersible films. At present, several patented technologies are commercially used in their production. They can be schematically divided into the productions by freeze-drying, compression, and forming by other methods.

Key words:
orodispersable tablets – dispersible films – production technologies – lyophilization – compression


Sources

1. Vetchý, D., Rabišková, M.: Dispergovatelné tablety a jejich použití v České republice. Čes. slov. Farm., 2007; 56, 46–47.

2. Vetchý, D.; Rabišková, M.: Orálně dispergovatelné tablety. Prakt. lékáren., 2007; 2, 181–183.

3. Thyssen, A., Remmerie, B., D’Hoore, P., Kushner, S., Mannaert, E.: Rapidly disintegrating risperidone in subjects with schizophrenia or schizoaffective disorder: A summary of ten phase I clinical trials assessing taste, tablet disintegration time, bioequivalence, and tolerability. Clin. Ther. 2007; 29, 290–304.

4. Biradar, S. S., Bhagavati, S. T., Kuppasad, I. J.: Fast Dissolving Drug Delivery Systems: A Brief Overview. Int. J. Pharmacol. 2006; 4. http://www.ispub.com/ostia/index. php?xmlFilePath=journals/ijpharm/vol4n2/drug.xml.

5. Pfister, W. R., Ghosh, T. K.: Orally Disintegrating Tablets - Products, Technologies, and Development Issues. Pharm. Technol., 2005; 29, 136–150.

6. Český lékopis 2009. Praha: Grada Publishing 2009; elektronická verze.

7. Verma, R. K., Garg, S.: Current Status of Drug Delivery Technologies and Future Directions. Pharm. Technol. On-line., 2001; 25, 1–14.

8. Khan, S., Kataria, P., Nalhat, P., Neole, P.: Taste Masking of Ondansetron Hydrochloride by Polymer Carrier System and Formulation of Rapid-Disintegrating Tablets. AAPS PharmSciTech. 2007; 8, Article 46. http://aapspharmscitech.org.

9. Crocq, M.-A., Guillon, M.-S., Bailey, P. E., Provost, E.: Orally disintegrating olanzapine induces less weight gain in adolescents than standard oral tablets. Eur. Psychiat., 2007; 22, 453–454.

10. Shen, Y.-Ch., Lee, M.-Y., Lin, Ch. C.H., Chen, Ch.-H.: Orally disintegrating olanzapine for the treatment of a manic patient with esophageal stricture plus chronic pharyngitis. Prog. Neuro-psych. Biol. Psych., 2007; 31, 541–542.

11. Haan, L., Amelsvoort, T., Rosien, K., Linszen, D.: Weight loss after switching from conventional olanzapine tablets to orally disintegrating olanzapine tablets. Psychopharmacology, 2004; 175, 389–390.

12. Camarco, W., ay, D., ruffner, A.: Selecting Superdisintegrants for Orally Disintegrating Tablet Formulations. Pharm. Technol., 2006; 30, 28–37.

13. Abdelbary, G., Prinderre, P., Eouani, C., Joachim, J., Reynier, J.P., Piccerelle, P.: The preparation of orally disintegrating tablets using a hydrophilic waxy binder. Int. J. Pharm., 2004; 278, 423–433.

14. Fast dissolve systems. http://www.informaworld.com/ (27. 11. 2007).

15. Bauer, K.H.: A partially freeze-dried lyophilization technology for producing fast–melting tablets - A new economical method for producing fast-melting lamina-like dosage forms Pharm. Technol. Europe., 2007; 6, http://www.ptemag.com/.

16. Sunada, H., Bi, Y.: Preparation, evaluation and optimization of rapidly disintegrating tablets. Powder Technol., 2002; 122, 188–198.

17. Yaginuma, Y., Yoshida, N.: Preparing rapid disintegrating tablets containing taste masking microgranules. Pharm. Technol. Europe., 2007; 6, http://www.ptemag.com/.

18. Bi, Y., Yorinobu, Y., Sunada, H.: Rapidly disintegrating tablets prepared by wet compression method: mechanism and optimization. J. Pharm. Sci., 1999; 88, 1004–1010.

19. Dobetti L.: Fast-Melting Tablets: Developments and Technologies. Pharm. Technol. Drug Delivery, 2001; Suppl, 44–50.

20. Kuno, Y., Kojima, M., Ando, S., Nakagami, H.: Evaluation of rapidly disintegrating tablets manufactured by phase transition of sugar alcohols. J. Control. Release., 2005; 105, 16–22.

21. Fukami, J., Yonemochi, E., Yoshihashi, Y., Terada, K.: Evaluation of rapidly disintegrating tablets containing glycine and carboxymethylcellulose. Int. J. Pharm., 2006; 310, 101–109.

22. Sammour, O. A., Hammad, M. A., Nehrab, N. A., Zidan, A. S.: Formulation and Optimization of Mouth Dissolve Tablets Containing Rofecoxib Solid Dispersion. AAPS PharmSciTech, 2006; 7, Article 55.

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Pharmacy Clinical pharmacology
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