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A study of the process of homogenization of powder mixtures using NIR spectroscopy


Authors: P. Doležel 1;  J. Muselík 1;  K. Dvořáčková 1;  K. Šustová 2
Authors‘ workplace: Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav technologie léků 1;  Mendelova univerzita v Brně, Agronomická fakulta, Ústav technologie potravin 2
Published in: Čes. slov. Farm., 2010; 59, 263-271
Category: Original Articles

Overview

The paper focuses on the use of NIR spectroscopy in the study of mixing powder mixtures. The study made use of model mixtures composed of diclofenac sodium salt, cetyl alcohol, povidon-30, sucrose and magnesium stearate. The measurement of NIR spectra was carried out with the use of a probe making it possible to scan the spectra direct from the homogenization vessel. The measured spectra were mathematically adjusted and subsequently processed by means of chemometric methods in order to obtain the predicate data on the course of mixing. The obtained data were evaluated by means of statistical methods and subsequently they were plotted into graphs in dependence on the time of mixing in order that the course of mixing could be well observable. The resulting graphs describing the course of mixing clearly show the stages of convective and diffuse mixing. The spectra which were statistically evaluated as remote were further studied in order to identify the causes of their origin. The other measurements included the data of physical properties of powders, namely flow density, Hausner ratio, and average particle size. The obtained data well illustrate the possibilities of NIR spectroscopy in the examination of the variability of the mixing process in time and document the suitability of NIR spectroscopy in the control of the process of mixing of powder mixtures.

Key words:
NIR spectroscopy – homogenization – convective mixing – diffuse mixing – chemometric methods


Sources

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Labels
Pharmacy Clinical pharmacology
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