Foveal Hypoplasia Detection by Optical Coherence Tomography

Authors: B. Bušányová;  M. Porubanová;  A. Gerinec
Authors‘ workplace: Klinika detskej oftalmológie DFNsP ;  LFUK, Bratislava prednosta kliniky prof. MUDr. Anton ;  Gerinec, CSc.
Published in: Čes. a slov. Oftal., 70, 2014, No. 1, p. 22-28
Category: Original Article


To evaluate the contribution of optical coherence tomography (OCT) in the diagnosis of foveal hypoplasia in children.

Material and methods:
Children with foveal hypoplasia (FH) were examinated with device RTVue Fourier – domain (FD) – OCT, software – version 6.8 (Optovue Inc., Fremont, USA). A qualitative examination of the macular area was performed with single horizontal scan (1024 A-scans/frame). Macular thickness was measured and evaluated quantitatively with an automatic fast macular area protocol MM5 (Macular Map 5x5 mm). A control group of children was used for comparison.

The quality was assessed with OCT image of the macula and quantitatively evaluated macular thickness and configuration in children with foveal hypoplasia. It was subsequently realized the comparison of macular OCT findings in healthy children. The OCT showed a reduction of foveal depression, continuous extension of the inner retinal layers through the area in which should be normally found fovea. Patients with foveal hypoplasia had thicker central macula and fovea than children in the control group.

OCT in our group of patients confirmed the final diagnosis of foveal hypoplasia. FD-OCT is a noninvasive and quick method helpful in identifying retinal abnormalities in the diagnosis of foveal hypoplasia in children and may be useful in diagnosing patients with unexplained decrease in vision.

Key words:
foveal hypoplasia, optical coherence tomography, children


1. Cronin, T.H., Hertle, R.W., Ishikawa, H. et al.: Spectral domain optical coherence tomography for detection of foveal morphology in patients with nystagmus. J AAPOS, 2009; 13(6): 563–566.

2. Dubis, A.M., Hansen, B.R., Cooper, R.F. et al.: Relationship between the Foveal Avascular Zone and Foveal Pit Morphology. Invest Ophthalmol Vis Sci, 2012; 53: 1628–1636.

3. Gerinec, A.: Detská oftalmológia. Martin, Osveta, 2005, 593 s.

4. Holmström, G., Eriksson, U., Hellgren, K. et al.: Optical coherence tomography is helpful in the diagnosis of foveal hypoplasia. Acta Ophthalmol, 2010; 88(4): 439–442.

5. Chong, G., Farsiu, S., Freedman, S.F. et al.: Abnormal Foveal Morphology in Ocular Albinism Imaged With Spectral-Domain Optical Coherence Tomograph. Arch Ophthalmol, 2009; 127(1): 37–44.

6. McAllistera, J.T., Dubisb, A.M., Taita, D.M. et al.: Arrested Development: High-Resolution Imaging of Foveal Morphology in Albinism. Vision Res, 2010; 50(8): 810–817.

7. Mohhamad, S., Gottlob, I., Kumar, A. et al.: The Functional Significance of Foveal Abnormalities in Albinism Measured Using Spectral-Domain Optical Coherence Tomography. Ophthalmology, 2011; 118:1645–1652.

8. Mota, A., Fonseca, S., Carneiro, A. et al.: Isolated Foveal Hypoplasia: Tomographic, Angiographic and Autofluorescence Patterns. Case Reports in Ophthalmological Medicine, 2012; 2012: 864–958.

9. Pal, S.S., Gella, L., Sharma, T. et al.: Spectral domain optical coherence tomography and microperimetry in foveal hypoplasia. Indian J Ophthalmol, 2011; 59(6): 503–505.

10. Park, K.A., Oh, S.Y.: Clinical characteristics of high grade foveal hypoplasia. Int Ophthalmol, 2013; 33: 9–14.

11. Rossi, S., Testa, F., Gargiulo, A. et al.: The Role of Optical Coherence Tomography in an Atypical Case of Oculocutaneous Albinism: A Case Report. Case Rep Ophthalmol, 2012; 3: 113–117.

12. Saffra, N., Agarwal, S., Chiang, J.P.W. et al.: Spectral-Domain Optical Coherence Tomographic Characteristics of Autosomal Recessive Isolated Foveal Hypoplasia. Arch Ophthalmol, 2012; 130(10): 1324–1327.

13. Seo, J.H., Yu, Y.S., Kim, J.H. et al.: Correlation of visual acuity with foveal hypoplasia grading by optical coherence tomography in albinism. Ophthalmology, 2007; 114(8): 1547–51.

14. Thomas, M.G., Kumar, A., Mohammad, S. et al.: Structural Grading of Foveal Hypoplasia Using Spectral-Domain Optical Coherence Tomography. Ophthalmology, 2011; 118: 1653–1660.

15. Yang, H., Yu, T., Sun, C. et al.: Spectral-domain optical coherence tomography in patients with congenital nystagmus. Int J Ophthalmol, 2011; 4(6): 627–630.

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