Current Overview of the Diabetic Macular Edema

Authors: T. Sosna 1,2;  R. Švancarová 2;  M. Netuková 3;  J. Studnička 4
Authors‘ workplace: Centrum diabetologie IKEM, Praha, přednostka prof. MUDr. Terezie Pelikánová, DrSc. 1;  Oční oddělení TN, Praha, primář MUDr. Karel Sedláček 2;  FNKV, Praha, přednosta prof. MUDr. Pavel Kuchynka, CSc. 3;  Oční klinika FN a LF UK, Hradec Králové, přednosta prof. MUDr. Pavel Rozsíval, CSc., FEBO 4
Published in: Čes. a slov. Oftal., 68, 2012, No. 3, p. 91-97
Category: Comprehensive Report


1. Aiello, L., Gardner, T., King, G. et al.: Diabetic Retinopathy. Diabetes Care 1998; 21: 143–156.

2. Arevalo, F.: Retina Angiography and Optical Coherence Tomography. Springer Science USA 2009; 471.

3. Aveleira, C., Lin, C., Abcouwer, S., Ambrosio, A., Antonetti, D.: TNF-alpha signals through PKCzeta/NF-kappaB to alter the tight junction complex and increase retinal endothelial cell permeability. Diabetes, 2010; 59: 2872–82.

4. Bandello, F.: Seminars in Ophthalmology, 2001, vol. 16, No1. pp. 2–41.

5. Brenick, G.: Diabetic maculopathy: a critical review highlighting diffuse macular edema. Ophthalmology, 1983; 1301–1317.

6. Bresnick, G.: Diabetic macular edema: e review. Ophthalmology, 1986; 93: 989–997.

7. Dodson, P.: Diabetic Retinopathy. Oxford University Press 2008; 17.2

8. Dodson, P.: Managing Diabetic retinopathy. nowPharma LTD. 2011; 84.

9. Duh, E.: Diabetic Retinopathy. Human press 2008; 494.

10. Diabetic retinopathy Clinical Research Network. A randomized Trial comparing intravitreal triamcinolone acetionicde and focal/grid photocoagulation for diabetic maculoar edema. Ophthalmology, 2008; 115: 1447–1459.

11. The Diabetic Retinopathy Clinical Research Network. Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology, 2010; 117(6):1064–1077.

12. Diabetes Control and Complications Trial Research Group (DCCT). The effect of intensive treatment of diabetes on the development and progression of long term complications in insulin-dependent diabetes mellitus. N Engl J Med, 1993; 329: 977–86.

13. Early Treatment Diabetic Retinopathy Study research group. Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study Report No.1 Arch Ophthalmol.1985; 103: 1796–1806.

14. Easty, L., Sparrow, J.: Oxford textbook of ophthalmology. New York: Oxford University Press 1999; 1308.

15. Gastinger, M, Kunselman, A, Conboy, E. et al.: Dendrite remodeling and other abnormalities in the retinal ganglion cells of Ins2 Akita diabetic mice. Incest Ophthalmol Vis Sci, 2008; 49: 2635–42.

16. Gowda, K, Zinnanti, W, LaNoue, K.: The influence of diabetes on glutamate metabolism in retinas. J Neurochem, 2011; 117: 309–20.

17. Hanas, R., John, G.: On behalf of the International HBA1c Consensus Committee: 2010 Consensus Statement on the Worldwide Standardization of the Hemoglobin A1C: Ann Clin Biochem, July 1, 2010; 47(4): 290–291.

18. Hotamisligil, S.: Inflammation and metabolic disorders. Nature, 2006; 444: 860–7.

19. Chew E., Klein M., Ferris F., et al.: Association of elevated serum lipid levels with retinal hard exudates in diabetic retinopathy. Arch Ophthalmol, 1996; 114: 1079–84.

20. Joussen, A., Poulaki, V., Mitsiades, N., et al.: Nonsteroidal anti-inflammatory drugs present early diabetic retinopathy via TNF-alpha suppression. FASEB J 2002; 16: 438–40.

21. Joussen, A, Poulaki, V, Qin, W, et al.: Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthese expression and initiates early diabetic retinal leukocyte adhesion in vivo. Am J Pathol, 2002; 160: 501–9.

22. Keech, A.C., Mitchell, P., Summanen, P., et al.: Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomized controlled trial. Lancet 2007; 370: 1687–97.

23. Klein, R., Klein, B., Moss, S., Mets, D.: Is blood pressure a predictor of the incidence or progression of diabetic retinopathy? Arch Int Med, 1989; 149: 2427 – 2432.

24. Klein, R., Klein, B., Moss, E., Devis, M., De Mets, L.: Glycosilated haemoglobin predicts the incidence and progression diabetic retinopathy. JAMA 1988; 260: 2864–71.

25. Kuchyňka, P. a kol.: Oční lékařství. Praha: Grada 2007; 768.

26. Larson, H, Polsen, J.: Intraocular tension and blood sugar fluctuation in diabetes. Acta Ophthalmol, 1962; 40: 580–9.

27. Massin, P., Bandello, F., Garweg, J., et al.: Safety and efficacy of ranibizumab in diabetic macular edema (RESOLVE study): a 12-month, randomized, controlled, doublemasked, multicenter phase II study. Diabetes Care, 2010.

28. Mitchell, P., Bandello, F., Schmidt-Erfurth, U. et al.: Ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macula edema. Ophthalmology, 2011; 118: 615–625.

29. Murphy, R.: Management of diabetic retinopathy. Am Fam Physician, 1995; 51, 4: 785–796.

30. Pelikánová, T., Bartoš, V.: Praktická diabetologie 5. vyd. Maxdorf 2011; 738.

31. Pickup, J, Williams, G.: Textbook of diabetes, 2nd ed. volume two. Oxford: Blackwell Science Ltd. 1997; n.p.

32. Ryan, J.: Retina. 3rd ed. volume two. St. Louise : Mosby, Inc. 2001; 1847.

33. Scanlon, P., Aldington, S., Wilkinson, Ch. et al.: Practical Manual of Diabetic Retinopathy Management. Wiley-Blackwel 2009; 232.

34. The ACCORD Study Group. Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial: design and methods. Am J Cardiol, 2007; 99: Suppl: 21-33.

35. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med, 1993; 329: 977–86.

36. Škrha, J. et al.: Diabetologie. Praha: Galén 2009; 417.

37. UK Prospective Diabetes Study (UKDPS) Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKDPS 38. B M J 1998; 317: 703–13.

38. VanGuilder, H., Brucklacher, A., Patel, K.  et al.: Diabetes downregulates presynaptic proteins and reduces basal synapsin1 phosphorylation in rat retina. Eur J Neurosci 2008; 28: 1–11.

39. Wang, J., Xu, X., Elliott, M., Zhu, M., LeYZ.: Müller cell-derived VEGF is Essentials for diabetes-induced retinal inflammation and vascular leakage. Diabetes 2010; 59:2297-305.

40. Williams, R, Herman, W, Kinmonth, AL, Wareham, NJ.: The Evidence Base for Diabetes Care. John Wiley & sons, LTD Englad, 2002. pp. 784.

Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account