#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

The Timing of Carotid Endarterectomy


Authors: J. Mraček;  I. Holečková;  J. Mork;  M. Choc
Authors‘ workplace: Neurochirurgické oddělení LF UK a FN Plzeň
Published in: Cesk Slov Neurol N 2008; 71/104(4): 414-421
Category: Review Article

Overview

The timing of carotid endarterectomy (CEA) after a stroke remains a controversial area. Surgery is still, for the most part, delayed for 4 to 6 weeks post stroke due to the risk of postoperative intracerebral hemorrhage. More recently prospective studies and meta‑analyses of existing data have shown this arbitrary delay to be unnecessary. The combined risk of stroke recurrence and delayed surgery is higher than the risk of an early endarterectomy. The division of surgery into acute and delayed is inadequate. The ti­ming of CEA should have three levels: 1. emergent, 2. urgent and 3. delayed based on the strength of three essential criteria: a) clinical status, b) angiographic characteristics and c) CT or MRI findings. With regard to timing, the performing of a CEA is mostly for secondary prevention but may advance to become a treatment for the original cause of the problem in a selected group of patients with acute ictus or haemodynamic strokes. This article reviews the background of timing in carotid endarterectomy performed post stroke.

Key words:
carotid endarterectomy – timing – emergency – urgent – elective – stroke – transient ischemic attack – intracerebral hemorrhage


Sources

1. European Carotide Surgery Trialists‘ Collaborative Group. MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70–90%) or with mild (0–29%) carotid stenosis. Lancet 1991; 337(8752): 1235–1243.

2. North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med 1991; 325(7): 445–453.

3. Barnett HJ, Taylor DW, Eliasziw M, Fox AJ, Fergusson GG, Haynes RB et al. Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med 1998; 339(20): 1415–1425.

4. Bond R, Rerkasem K, Rothwell PM. Systematic review of the risk of carotid endarterectomy in relation to the clinical indication for and timing of surgery. Stroke 2003; 34(9): 2290–2301.

5. Bruetman ME, Fields WS, Crawford ES, DeBakey ME. Cerebral hemorrhage in carotid artery surgery. Arch Neurol 1963; 9: 458–467.

6. Wylie EJ, Hein MF, Adams JE. Intracranial hemorrhage following surgical revascularization for treatment of acute strokes. J Neurosurg 1964; 21: 212–215.

7. Giordano JM, Trout HH 3rd, Kozloff L, DePalma RG. Timing of carotid artery endarterectomy after stroke. J Vasc Surg 1985; 2(20): 250–255.

8. Blaisdell WF, Clauss RH, Galbraith JG, Imprato AM, Wylie EJ. Joint study of extracranial arterial occlusion. IV. A review of surgical consideration. JAMA 1969; 209(12): 1889–1895.

9. Thompson JE, Talkington CM. Carotid endarterectomy. Ann Surg 1976; 184(1): 1–15.

10. Little JR, Moufarrij NA, Furlan AJ. Early carotid endarterectomy after cerebral infarction. Neurosurgery 1989; 24(3): 334–338.

11. Dosick SM, Whalen RC, Gale SS, Brown OW. Carotid endarterectomy in the stroke patient: computerized axial tomography to determine timing. J Vasc Surg 1985; 2(1): 214–219.

12. Khanna HL, Garg AG. 774 carotid endarterectomies for strokes and transient ischemic attacks: comparison of results of early vs. late surgery. Acta Neurochir Suppl (Wien) 1988; 42: 103–106.

13. Sacco RL, Foulkes MA, Mohr JP, Wolf PA, Hier DB, Price TB. Determinants of early recurrence of cerebral infarction. The Stroke Data Bank. Stroke 1989; 20(8): 983–989.

14. Gasecki AP, Ferguson GG, Eliasziw M, Clagett GP, Fox AJ, Hatchinski V et al. Early endarterectomy for severe carotid artery stenosis after a nondisabling stroke: results from the North American Symptomatic Carotid Endarterectomy Trial. J Vasc Surg 1994; 20(2): 288–295.

15. Davenport RJ, Dennis MS, Wellwood I, Warlow CP. Complications after acute stroke. Stroke 1996; 27(3): 415–420.

16. Hunter JA, Julian DC, Dye WS Javid H. Emergency operation for acute cerebral ischemia due to carotid artery obstructions. Ann Surg 1965; 162(5): 901–904.

17. Rob CG. Operation for acute completed stroke due to thrombosis of the internal carotid artery. Surgery 1969; 65(5): 862–865.

18. Ballota E, Da Giau G, Barachini C, Abbruzzese E, Saladini M, Meneghetti G. Early versus delayed carotid endarterectomy after a nondisabling ischemic stroke: a prospective randomized study. Surgery 2002; 131(3): 287–293.

19. Rothwel PM, Eliasziw M, Gutnikov SA, Warlow CP, Barnett HJM. Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery. Lancet 2004; 363(9413): 915–924.

20. Gasecki AP, Eliasziw M. Timing of carotid endarterectomy after stroke. Stroke 1998; 29 (12): 2667–2668.

21. Beebe HG, Clagett GP, DeWeese JA, Moore WS, Robertson JT, Sandok B et al. Assessing risk associated with carotid endarterectomy: a statement for health professional by an Ad Hoc Committee on Carotid Surgery Standards of the Stroke Council, American Heart Association. Circulation 1989; 79: 472–473.

22. Biller J, Feinberg WM, Castaldo JE, Whittemore AD, Harbaugh RE, Dempsey RJ et al. Guidelines for carotid endarterectomy: a statement for healthcare professionals from a Special Writing Group of the Stroke Council, American Heart Association. Stroke 1998; 29(2): 554–562.

23. Moore WS, Barnett HJ, Beebe HG, Bernstein EF, Brener BJ, Brott T at al. Guidelines for carotid endarterectomy. A multidisciplinary consensus statement from the Ad Hoc Committee, American Heart Association. Stroke 1995; 26(1): 188–201.

24. Goldstein LB, Adams R, Beckter K, Furberg CD, Gorelick PB, Hademenos G et al. Primary prevention of ischemic stroke: A statement for healthcare professionals from the Stroke Council of the American Heart Association. Stroke 2001; 32(1): 280–299.

25. Pritz MB. Timing of carotid endarterectomy after stroke. Stroke 1997; 28(12): 2563–2567.

26. Walters BB, Ojemann RG, Heros RC. Emergency carotid endarterectomy. J Neurosurg 1987; 66(6): 817–823.

27. Harrison MJ, Marshall J. The finding of thrombus at carotid and its relationship to the timing of surgery. Br J Surg 1977; 64(7): 511–512.

28. Caplan LR, Skillman J, Ojemann R, Fields WS. Intracerebral hemorrhage following carotid endarterectomy: a hypertensive complication? Stroke 1978; 9(5): 457–460.

29. Baron EM, Baty DE, Loftus CM. The timing of carotid endarterectomy post stroke. Neurol Clin 2006; 24(4): 669–680.

30. Whittemore AD, Ruby ST, Couch NP, Mannick JA. Early carotid endarterectomy in patients with small, fixed neurologic deficits. J Vasc Surg 1984; 1(6): 795–799.

31. Rosenthal D, Borrero E, Clark MD, Lamis PA, Daniel WW. Carotid endarterectomy after reversible ischemic neurologic deficit or stroke: is it of value? J Vasc Surg 1988; 8(4): 527–534.

32. Piotrowski JJ, Bernard VM, Rubin JR, McIntyre KE, Malone JM, Parent FN III et al. Timing of carotid endarterectomy after acute stroke. J Vasc Surg 1990; 11(1): 45–51.

33. Hoffmann M, Robbs J. Carotid endarterectomy after recent cerebral infarction. Eur J Vasc Endovasc Surg 1999; 18(1): 6–10.

34. Wolfle KD, Pfadenhauer K, Bruijnen H, Becker T, Engelhardt M, Wachenfeld–Wahl C et al. Early carotid endarterectomy in patients with a nondisabling ischemic stroke: results of a retrospective analysis. Vasa 2004; 33(1): 30–35.

35. Rockman CB, Maldonado TS, Jacobowitz GR, Cayne NC, Gagne PJ, Riles TS. Early carotid endarterectomy in symptomatic patients is associated with poorer perioperative outcomes. J Vasc Surg 2006; 44(3): 480–487.

36. Mead GE, Murray H, Farrell A, O´Neill PA, McCollum CN. Pilot study of carotid surgery for acute stroke. Br J Surg 1997; 84(7): 990–992.

37. Graber JN, Vollman RW, Johnson WC, Levine H, Butler R, Scott RM et al. Stroke after carotid endarterectomy: risk as predicted by preoperative computerized tomography. Am J Surg 1984; 147(4): 492–497.

38. Riccota JJ, Ouriel K, Green RM, DeWeese JA. Use of computerized cerebral tomography in selection of patients for elective and urgent carotid endarterectomy. Ann Surg 1985; 202(6): 783–787.

39. Ševčík P, Polívka J, Hess Z. Cerebrovaskulární rezerva bazilární a střední mozkové tepny. Komparativní studie s použitím transkraniální dopplerometrie a CO2. Cesk Slov Neurol N 2005; 68/101(6): 378–381.

40. Benavente O, Eliasziw M, Streifler JY, Fox AJ, Barnett HJ, Meldrum H. Prognosis after transient monocular blindness associated with carotid-artery stenosis. N Engl J Med 2001; 345(15): 1084–1090.

41. Gladstone DJ, Kapral MK, Fang J, Laupacis A, Tu JV. Management and outcomes of transient ischemic attacks in Ontario. CMAJ 2004; 170(7): 1099–1104.

42. Gladstone DJ. Commentary: Toward an emergency response to transient ischemic attacks. Postgrad Med 2005; 117(1): 9–14.

43. Johnston SC. Clinical practice. Transient ischemic attack. N Engl J Med 2002; 374(21): 1687–1692.

44. Lovett JK, Dennis MS, Sandercock PA, Bamford J, Warlow CP, Rothwell PM. Very early risk of stroke after a first transient ischemic attack. Stroke 2003; 34(8): 138–140.

45. Coull AJ, Lovett JK, Rothwell PM, Oxford Vascular Study. Population ba­sed study of early risk of stroke after transient ischemic attack or minor stroke: implications for public education and organisation of services. BMJ 2004; 328 (7435): 326.

46. Eliasziw M, Kennedy J, Hill MD, Buchan AM, Barnett HJ; North American Symptomatic Carotid Endarterectomy Trial Group. Early risk of stroke after a transient ischemic attack in patients with internal carotid artery disease. CMAJ 2004; 170(7): 1105–1109.

47. The Dutch TIA Trial Study Group. Predictors of major vascular events in patients with transient ischemic attack and nondisabling stroke. Stroke 1993; 24: 527–531.

48. Amin-Hanjani S, Ogilvy CS. Indications and techniques for emergent carotid exploration. In: Loftus CM, Kresowik TF (eds). Carotid artery surgery. New York: Thieme 2000: 303–313.

49. Mentzer RM jr, Finkelmeier BA, Prosby IK, Wellons HA jr. Emergency carotid endarterectomy for fluctuating neurologic deficits. Surgery. 1981; 89(1): 60–66.

50. Diaz FG, Ausman JI, Mehta B, Dujovny M, de los Reyes RA, Pearce J et al. Acute cerebral revascularization. J Neurosurg 1985; 63(2): 200–209.

51. Nehler MR, Moneta GL, McConnell DB, Edwards JM, Taylor LM jr, Yeager RA et al. Anticoagulation followed by elective carotid surgery in patients with repetitive transient ischemic attacks and high-grade carotid stenosis. Arch Surg 1993; 128(10): 1117–1123.

52. Loftus CM. Propagating intraluminal carotid thrombus – surgery or anticoagulations? In: Loftus CM, Kresowik T (eds). Carotid Artery surgery. New York: Thieme Medical Publishers 2000: 321–328.

53. Adams HP, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A et al. Guidelines for the early management of adults with ischemic stroke. Stroke 2007; 38(5): 1655–1711.

54. Taylor CL, Seman WR, Grubb RL Jr, Ratcheson RA. Ischemic complications of carotid endarterectomy. In: Loftus CM, Kresowik TF (eds): Carotid artery surgery. New York: Thieme Medical Publishers 2000: 471–477.

55. Findlay JM, Marchak BE. Reoperation for acute hemispheric stroke after carotid endarterectomy: is there any value? Neurosurgery 2002; 50(3): 486–492.

56. Meyer FB, Sundt TM Jr, Piepgras DG, Sandok BA, Forbes G. Emergency carotid endarterectomy for patients with acute carotid occlusion and profound neurological deficits. Ann Surg 1986; 203(1): 82–89.

57. Beneš V, Steindler J. Urgentní desobliterace vnitřní krkavice u nemocných s těžkým neurologickým deficitem. Cesk Slov Neurol N 1994; 57/90(4): 143–149.

58. Van der Mieren G, Duchateau J, De Vleeschauwer P, De Leersnijder J. The case for urgent carotid endarterectomy. Acta Chir Belg 2005; 105(4): 403–406.

59. Peiper C, Nowack J, Ktenidis K, Hopstein S, Keresztury G, Horsch S. Prophylactic urgent revascularization of the internal carotid artery in the symptomatic patient. Vasa 2001; 30(4): 247–251.

60. Huber R, Müller BT, Seitz RJ, Siebler M, Mödder U, Sandmann W. Carotid surgery in acute symptomatic patients. Eur J Vasc Endovasc Surg 2003; 25(1): 60–67.

61. Gay JL, Curtil A, Buffiere S, Favre JP, Barral X. Urgent carotid artery repair: retrospective study of 21 cases. Ann Vasc Surg 2002; 16(4): 401–406.

62. Schneider C, Johansen K, Königstein R, Metzner C, Oettinger W. Emergency carotid thromboendarterectomy: safe and effective. World J Surg 1999; 23(11): 1163–1167.

63. Herzig R, Král M, Olivier P, Šaňák D, Bachleda P, Utíkal P et al. Ischemický iktus podmíněný akutní okluzí ACI: roční outcome pa­cientů léčených akutní CEA a IVT. Cesk Slov Neurol N 2007; 70/103(Suppl): 7.

64. Pistolese GR, Ventura M, Speziale F, Fiorani P. Emergency carotid surgery. Int Surg 1984; 69(3) 231–234.

65. Rothwell PM, Warlow CP, for the European Carotid Surgery Trialists´ Collaborative Group. Low risk of ischemic stroke in patients with reduced internal carotid artery lumen diameter distal to severe symptomatic carotid stenosis: cerebral protection due to low poststenotic flow? Stroke 2000; 31(3): 622–630.

66. Morgenstern LB, Fox AJ, Sharpe BL, Eliasziw M, Barnett HJM, Grotta JC, for the North American Symptomatic Carotid Endarterectomy Trial (NASCET) Group. The risk and benefits of carotid endarterectomy in patients with near occlusion of the carotid artery. Neurology 1997; 48(4): 911–915.

67. Blaser T, Hofmann K, Buerger T, Effenberger O, Wallesch CW, Goertler M. Risk of stroke, transient ischemic attack, and vessel occlusion before endarterectomy in patients with symptomatic severe carotid stenosis. Stroke 2002; 33(4): 1057–1062.

68. Rothwell PM, Gibson R, Warlow CP. Interrelation between plaque surface morphology and degree of stenosis on carotid angiograms and the risk of ischemic stroke in patients with symptomatic carotid stenosis. Stroke 2000; 31(3): 615–621.

69. Eliasziw M, Streifler JY, Fox AJ, Hachinski VC, Ferguson GG, Barnett HJ. Significance of plaque ulceration in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial. Stroke 1994; 25(2): 304–308.

70. Markus H, Cullinane M. Severely impaired cerebrovascular reactivity predicts stroke and TIA risk in patients with carotid artery stenosis and occlusion. Brain 2001; 124(3): 457–467.

71. Vernieri F, Pasqualetti P, Passarelli F, Rossini PM, Silvestrini M. Outcome of carotid artery occlusion is predicted by cerebrovascular reactivity. Stroke 1999; 30(3): 593–598.

72. Biller J, Adams HP, Boarini D, Godersky JC, Smoker WR, Kongable G. Intraluminal clot of the carotid artery. A clinical-angiographic correlation of nine patients and literature review. Surg Neurol 1986; 25(5): 467–477.

73. Buchan A, Gates P, Pelz D, Barnett HJ. Intraluminal thrombus in the cerebral circulation. Implications for surgical management. Stroke 1988; 19(6): 681–697.

74. Heros RC. Carotid endarterectomy in patients with intraluminal thrombus. Stroke 1988; 19(6): 667–668.

75. MRC Asymptomatic Carotid Surgery Trial (ACST) Collaborative Group. Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomized controlled trial. Lancet 2004; 363(9420): 1491–1502.

76. Paty PS, Darling RC 3rd, Woratyla S, Chang BB, Kreienberg PB, Shah DM. Timing of carotid endarterectomy in patients with recent stroke. Surgery 1997; 122(4): 850–854.

77. Toni D, Fiorelli M, Bastianello S, Sacchetti ML, Sette G, Argentino C et al. Hemorrhagic transformation of brain infarct: predictability in the first 5 hours from stroke onset and influence on cli­nical outcome. Neurology 1996; 46(2): 341–345.

78. Cerebral Embolism Study Group. Immediate anticoagulation of embolic stroke: brain hemorrhagie and management options. Stroke 1984; 15(5): 779–789.

79. Mraček J, Choc M, Richtr P, Holeč­ková I, Šlauf F. Hyperperfúzní syndrom Cesk Slov Neurol N 2005; 68/101(3): 192–197.

80. Solomon RA, Loftus CM, Quest DO, Correll JW. Incidence and etiology of intracerebral hemorrhage following carotid endarterectomy. J Neurosurg 1986; 64(1): 29–34.

81. Hafner DH, Smith RB 3rd, King OW, Perdue GD, Steward MT, Rosenthal D et al. Massive intracerebral hemorrhage following endarterectomy. Arch Surg 1987; 122(3): 305–307.

82. Schroeder T, Sillesen H, Boesen J, Laursen H, Sorensen PS. Intracerebral hemorrhage after carotid endarterectomy. Eur J Vasc Surg 1987; 1(1): 51–60.

83. Piepgras DG, Morgan MK, Sundt TM Jr, Yanagihara T, Mussman LM. Intracerebral hemorrhage after carotid endarterectomy. J Neurosurg 1988; 68(4): 532–536.

84. Henderson RD, Phan TG, Piepgras DG, Wijdicks FM. Mechanisms of intracerebral hemorrhage after carotid endarterectomy. J Neurosurg 2001; 95(6): 964–969.

85. Coutts SB, Hill MD, Hu WY. Hyper­perfusion syndrome: toward a stricter definition. Neurosurgery 2003; 53(5): 1053–1060.

86. Bernstein M, Fleming JF, Deck JH. Cerebral hyperperfusion after carotid endarterectomy: a cause of cerebral hemorrhage. Neurosurgery 1984; 15(1): 50–56.

87. Baker CJ, Mayer SA, Prestigiacomo CJ, Van Heertum RL, Salomon RA. Diagnosis and monitoring of cerebral hyperperfusion after carotid endarterectomy with single photon emission computed tomography: case report. Neurosurgery 1998; 43(1):157–160.

88. Penn AA, Schomer DF, Steinberg GK. Imaging studies of cerebral hyperperfusion after carotid endarterectomy. J Neurosurg 1995; 83(1): 133–137.

Labels
Paediatric neurology Neurosurgery Neurology

Article was published in

Czech and Slovak Neurology and Neurosurgery

Issue 4

2008 Issue 4

Most read in this issue
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#