Successful Therapy of Czech Patients with ROS1 Translocation by Crizotinib

Authors: M. Svaton;  M. Pešek
Authors‘ workplace: Klinika pneumologie a ftizeologie LF UK a FN Plzeň
Published in: Klin Onkol 2016; 29(1): 63-65
Category: Case Report
doi: 10.14735/amko201663


Targeted therapy of lung cancer has brought significant improvement in prognosis for a lot of patients with EGFR-sensitive mutations and ALK translocations. Other clinical studies have shown ROS1 translocation as another potential target. Our case report brings probably the first successful use of crizotininib in a patient with ROS1 translocation in the Czech Republic. Treatment was well-tolerated and persists continually. During the control PET/ CT scans, partial regression of the disease was observed. ROS1 translocation becomes another promising target for our patients. Therefore, in our opinion, serious discussion about its inclusion among the basic genetic testing in lung adenocarcinomas should occur.

Key words:
non-small cell lung cancer – ROS1 – crizotinib

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.

3. 11. 2015

7. 12. 2015


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