Adenoviral Vectors in Gene Therapy


Authors: M. Pjechová 1;  L. Hernychová 1;  P. Tomašec 1,2;  G. W. Wilkinson 1,2;  B. Vojtěšek 1
Authors‘ workplace: Regionální centrum aplikované molekulární onkologie, Masarykův onkologický ústav, Brno 1;  Department of Medical Microbio­logy, Institute of Infection and Immunity, School of Medicine, Cardiff University, United Kingdom 2
Published in: Klin Onkol 2015; 28(Supplementum 2): 75-80
doi: 10.14735/amko20152S75

Overview

This review is focused on gene therapy, especially adenovirus vectors and their relationship with the immune system response. Adenovirus vectors belong to the most used gene delivery vehicles in gene therapy, study of gene expression or immunotherapy. One of the most important questions concerning their use is their influence on organism in vivo. Study of immunomodulating properties of the adenovirus vectors opens a way for further manipulation and their more effective practical use.

Key words:
gene therapy –  adenoviridae –  immune system

This study was supported by the European Regional Development Fund and the State Budget of the Czech Republic (RECAMO, CZ.1.05/2.1.00/03.0101), by the project MEYS – NPS I – LO1413 and by (MH CZ – DRO (MMCI, 00209805).

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Submitted:
2. 4. 2015

Accepted:
20. 7. 2015


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