Is the Same Tyrosine Kinase Inhibitor Still Effective After Development of Brain Metastases? A Case Report

Authors: J. Obertova;  M. Mego;  P. Palacka;  J. Rajec;  M. Chovanec;  J. Mardiak
Authors‘ workplace: II. onkologická klinika LF UK a Národný onkologický ústav, Bratislava
Published in: Klin Onkol 2013; 26(4): 286-290
Category: Case Report


There is a new era of treatment options since introduction of new biological targeted therapies (tyrosine kinase inhibitors (TKIs) and mammalian target of rapamycin (mTOR) inhibitors) in renal cell cancer. However, in patients who developed brain metastases, there is still treatment dilemma about an optimal therapeutic scenario, particularly in the subgroup of patients with­out disease progression outside the central nervous system. The objective of this case report is to present that it is possible to continue the same targeted therapy after development of brain metastasis after application of local whole brain irradiation with meaningful overall survival.

Key words:
renal cell cancer – brain metastases – targeted therapy – sunitinib


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