Intoxication with ethylene glycol and falsely increased plasma lactate concentration
Authors:
J. Racek 1; V. Petříková 1; D. Rajdl 1; I. Novák 2
Authors‘ workplace:
Ústav klinické biochemie a hematologie
1; I. interní klinika Lékařské fakulty UK a Fakultní nemocnice v Plzni
2
Published in:
Klin. Biochem. Metab., 25, 2017, No. 1, p. 32-35
Overview
Objective:
To describe a patient intoxicated with ethylene glycol and to show possible problems of delayed diagnosis due to interference of ethylene glycol oxidative products in lactate determination.
Design:
Case report and evaluation of laboratory results.
Settings:
Department of Clinical Biochemistry and Hematology and Ist Department of Internal Medicine, Faculty of Medicine, Charles University and Faculty Hospital, Alej Svobody 80, 304 60 Pilsen (Czech Republic).
Material and Methods:
Case report.
Results:
The paper describes a patient intoxicated with ethylene glycol including diagnostic consideration, worsened by falsely increased concentration of lactate, measured amperometrically using blood-gas analyzers.
Conclusion:
Products of ethylene glycol oxidation (glycolic and glyoxylic acids) are the cause of falsely increased concentration of lactate when measured by a lactate enzymatic electrode with lactate oxidase and amperometric detection.
Keywords:
ethylene glycol, glyoxylate, lactate, interference.
Sources
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3. Duncan, R. J. S., Tipton, K. F.: The oxidation and reduction of glyoxylate by lactic dehydrogenase. European J. Biochem., 1969, (11), p. 58 – 61
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16. Reference manual for ABL800 FLEX (Radiometer), kap. 5, s. 5-95
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Labels
Clinical biochemistry Nuclear medicine Nutritive therapistArticle was published in
Clinical Biochemistry and Metabolism
2017 Issue 1
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