Presepsin as a diagnostic and prognostic tool for sepsis


Authors: M. Beňovská 1,2;  D. Bučková 1;  D. Petříková 2;  J. Stašek 3;  J. Gottwaldová 1,2
Authors‘ workplace: Oddělení klinické biochemie, FN Brno 1;  Katedra laboratorních metod, Lékařská fakulta, MU Brno 2;  Klinika anesteziologie, resuscitace a intenzivní medicíny, FN Brno a LF MU Brno 3
Published in: Klin. Biochem. Metab., 23 (44), 2015, No. 3, p. 89-94

Overview

Objective:
To compare the results of presepsin determination with the results of the routinely used method of procalcitonin (PCT) determination on patients with sepsis. We use individual casuistries to describe the diagnostic significance of presepsin compared with PCT and their identical and different properties.

Material and Methods:
From the original cohort of patients treated for sepsis in University Hospital Brno, 31 individuals with long-term monitoring of procalcitonin and CRP sepsis markers were selected, and measured simultaneously for presepsin. The patients were further divided into two groups - 23 survivors and 8 non-survivors. Four casuistries are described in detail.Analysis of presepsin was carried out using chemiluminescent enzyme immunoassay on the fully automated POCT instrument PATHFAST from Mitsubishi Chemical.

Results:
The concentration of presepsin and PCT was compared between survivors and non-survivors. The evaluation of the results was based on samples from the first day after admission or development of sepsis, the day when the parameters reached the maximum value, and the date when monitoring of the septic condition was terminated (termination of hospitalization, exitus). A statistically significant difference between both groups was found at admission and at the end of sepsis monitoring for both presepsin (P=0.023 resp. P=0.002) and PCT (P=0.021 resp. P=0.0003). The given casuistries demonstrate that presepsin stays high in cases with a bad prognosis when compared to PCT.

Conclusions:
Like PCT, presepsin is a suitable marker for diagnosis, monitoring and prognosis of sepsis. Our results and findings in the latest literature even indicate that presepsin is superior to procalcitonin as a prognostic marker of sepsis.

Keywords:
presepsin, procalcitonin, sepsis, bacterial infection.


Sources

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