Hypercholesterolemia in pregnancy - pathobiochemical and pathophysiological implication for atherosclerosis and evaluation in metabolic surgery
Authors:
J. Hyánek
Authors‘ workplace:
Metabolická ambulance, Oddělení klinické biochemie, hematologie a imunologie, Nemocnice Na Homolce, Praha
Published in:
Klin. Biochem. Metab., 21 (42), 2013, No. 4, p. 208-214
Overview
After huge pathobiochemical and pathophysiological explanations of dyslipidemias in pregnancy, the autor presents an increase of total cholesterol about 30% in healthy women within 2nd trimester as physiological pregnancy hypercholesterolemia. The same increase in patients suffering from familial hypercholesterolemia draws more metabolic attention and needs some diagnostic and therapeutic support. Experimental studies on cholesterol synthesis in animal fetuses as totally independent on maternal cholesterol pool have been proved. The epidemiological studies in children born to mothers suffering from hypercholesterolemias proved none typical or serious defects till now. At the end he comments the medical treatment of pregnancy hypercholesterolemia that has never been accepted. Till now only laboratory experiments in animals and in human placental trophoblast cells proved the detrimental effected of high doses of statins on early embryonic development of different organs.
Keywords:
hypercholesterolemia in pregnancy, familial hypercholesterolemia, mixed familial dyslipidemia, menarche, sonic hedgehog protein, statins in pregnancy
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Clinical Biochemistry and Metabolism
2013 Issue 4
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