Ularitide in the treatment of acute heart failure decompensation – results of the TRUE-AHF trial


Authors: O. Ludka
Authors‘ workplace: Interní kardiologická klinika LF MU a FN Brno ;  Mezinárodní centrum klinického výzkumu, FN u sv. Anny v Brně
Published in: Kardiol Rev Int Med 2017, 19(3): 172-176

Overview

The primary hypothesis of the study was that ventricular distension during acute heart failure leads to myocardial injury, which would explain why such episodes of acute decompensation accelerate or worsen the course of the disease. The results showed that early vasodilation leads to significant decongestion and reduces cardiac-wall stress and rates of in-hospital worsening of heart failure. However, this positive effect did not reduce myocardial injury, nor did it change the prognosis of these patients, including the long-term risk of cardiovascular death.

Keywords:
acute heart failure decompensation – ularitide


Sources

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3. Packer M, O'Connor C, McMurray JV et al. Effect of ularitide on cardiovascular mortality in acute heart failure. N Engl J Med 2017; 376(20): 1956– 1964. doi: 10.1056/ NEJMoa1601895.

4. Metra M, Ponikowski P, Cotter G et al. Effects of serelaxin in subgroups of patients with acute heart failure: results from RELAX-AHF. Eur Heart J 2013; 34(40): 3128– 3136. doi: 10.1093/ eurheartj/ eht371.

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Labels
Paediatric cardiology Cardiac surgery Cardiology
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