Dual inhibition of the angiotensin receptor and neprilysin – revolutionary principle of treatment of chronic heart failure with reduced left ventricular ejection fraction

Czech version

Authors: F. Málek
Authors‘ workplace: Kardiocentrum, Nemocnice Na Homolce, Praha
Published in: Kardiol Rev Int Med 2016, 18(4): 281-286

Overview

Results of a PARADIGM-HF study (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial) were presented and published in 2014. The study showed favourable effect of a new drug group represented by sacubitril-valsartan on the outcome of patients with chronic heart failure with reduced ejection fraction. Drug with original code LCZ696 comprised of sacubitril – neprilysin inhibitor, and AT1 angiotensin II receptor blocker valsartan. Sacubitril-valsartan is an example of a new drug group entitled: angiotensin receptor neprilysin inhibitor.

Keywords:
chronic heart silure - mortality – angiotensin II – neprilysin – sacubitril-valsartan

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