Series of complications after heart transplantation – a case report

Authors: T. Honěk 1,2;  J. Krejčí 1,2;  P. Němec 2,3;  Z. Adam 4;  V. Žampachová 5;  V. Feitová 6;  L. Špinarová 1
Authors‘ workplace: I. interní kardioangiologická klinika LF MU a FN u sv. Anny v Brně 1;  Mezinárodní centrum klinického výzkumu, FN u sv. Anny v Brně 2;  Centrum kardiovaskulární a transplantační chirurgie, Brno 3;  Interní hematologická a onkologická klinika LF MU a FN Brno 4;  I. patologicko-anatomický ústav, LF MU a FN u sv. Anny v Brně 5;  Klinika zobrazovacích metod LF MU a FN u sv. Anny v Brně 6
Published in: Kardiol Rev Int Med 2014, 16(6): 476-480
Category: Cardiology Review


Orthotopic heart transplantation is an established method of treatment for patients with end‑stage heart failure, which improves the survival of these patients. The use of immunosuppressive therapy comes at the price of a number of potential risks, the most serious being infectious complications. Our case report describes a patient with heart failure on the basis of primary amyloidosis who underwent cardiac transplantation. Hemato‑ oncological curative treatment was planned after transplantation, but has not been applied due to the complete remission of the primary disease. In the early post‑transplant period, the patient experienced a number of complications, the most serious being invasive pulmonary aspergillosis. This infection was successfully controlled using voriconazole, and 28 months after heart transplantation the patient is now in good clinical condition with no signs of active infection.

orthotopic heart transplantation –  primary amyloidosis –  endomyocardial bio­psy –  invasive pulmonary aspergillosis


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Paediatric cardiology Internal medicine Cardiac surgery Cardiology

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