Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors

Authors: Ján Murín
Authors‘ workplace: I. interná klinika LF UK a UN Bratislava, nemocnica Staré mesto
Published in: AtheroRev 2016; 1(3): 151-154
Category: Reviews


Cardiovascular diseases contribute in Slovakia with 53 % to all-cause mortality. These diseases have usually an atherogenic background and the development of these diseases is impossible without an increase in serum LDL-cholesterol. For prevention and treatment of these diseases we use a change of life style and statins, but now a new group of drug will enter this arena – PCSK9 inhibitors. Author presents essential data about mechanisms of effects of these new drugs, about short history of these drugs development and presents important clinical studies with these drugs. He tries to focus on patients who will benefit mostly from this treatment.

Key words:
atherosclerosis – cardiovascular diseases – LDL-cholesterol – PCSK9 inhibitors


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