Peripheral arterial disease (PAD) of lower extremity and dyslipidemia


Authors: Denisa Čelovská;  Viera Štvrtinová;  Andrej Dukát
Authors‘ workplace: II. interná klinika LF UK a UN Bratislava
Published in: AtheroRev 2016; 1(3): 138-143
Category: Reviews

Overview

Peripheral arterial disease (PAD) of lower extremity is predominantly a manifestation of atherothrombotic process. Effective cardiovascular (CV) risk treatment is underestimated in clinical practice despite significantly increased cardio-cerbrovascular mortality and morbidity in symptomatic and even in asymptomatic PAD patients. Atherogenic dyslipidemia is a significant risk factor for vascular risk stratification in PAD patients. PAD patients have very high CV risk and the goal level of LDL cholesterol is less than 1.8 mmol/l or even lower according to new studies. First line therapy in PAD patients is statin treatment. However, in not reaching the LDL-cholesterol goal level conveniently, ezitimibe is added. PCSK9 inhibitors are a new perspective in high risk patients and in statin intolerance. What cannot be forgotten is modification of life-style especially in reduction of remnant lipoproteins, which play an important role in peripheral circulation.

Key words:
peripheral arterial disease of lower extremity – dyslipidemia – cardiovascular risk


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Labels
Angiology Diabetology Internal medicine Cardiology General practitioner for adults
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