High prevalence of cardiovascular risk factors and inadequate control of LDL cholesterol levels in the population of 40-year old men and 50-year old women in the Czech Republic

Authors: Zdeněk Chmelík 1;  Michal Vrablík 1;  Martina Vaclová 1;  Věra Lánská 2
Authors‘ workplace: III. interní klinika – klinika endokrinologie a metabolismu, 1. LF UK a VFN v Praze 1;  Institut klinické a experimentální medicíny, oddělení hygieny, Praha 2
Published in: AtheroRev 2016; 1(3): 111-115


The aim of the study was to assess a cardiovascular (CV) risk profile in the population of 40-year old men and 50-year old women stratified for CV risk and discuss the effectiveness of control of LDL cholesterol levels.

The study included 961 men at an average age of 42.9 ± 4.7 years and 851 at an average age of 51.2 ± 3.6 years. A questionnaire method was used to collect data concerning personal, pharmacological and family anamneses including results of laboratory examinations. The results were statistically evaluated and the following parameters were calculated: average, standard deviation, median and the first quartile. The CV risk was established using a SCORE algorithm with modifications as recommended by the guidelines.

The distribution of CV risk within the followed cohort: 24 % of probands were at low risk, 51 % at moderate risk, 17 % at high and 8 % at very high CV risk. The proportion of patients who reached LDL cholesterol target levels was dramatically lower in the cohorts with very high (3 %) or high (10 %) risk than in the cohorts with moderate (31 %) or low risk (59 %). The incidence of dyslipidemia was 20 %, equal in both genders. Arterial hypertension was newly diagnosed in 8 % of men and 5 % of women and type 2 diabetes mellitus was a new diagnosis for 3 % of both men and women. Prevalence of dyslipidemia reached 39 % for men and 41 % for women, arterial hypertension 43 % for men and 45 % for women and type 2 diabetes mellitus had been diagnosed earlier in 11 % of men and women alike. 56 % of 101 patients with LDL cholesterol > 5 mmol/l were not treated with statin.

The European recommendations propose that population-wide screening for risk factors including a lipid profile analysis should be considered for the populations of 40-year old men and 50-year old or postmenopausal women. High prevalence and incidence of CV risk factors, including a poor level of their control, was identified in the followed cohort. This finding leads to the idea that preventive check-ups at a younger age should be con­sidered (e.g. in 30-year old men and 40-year old women). Of course this hypothesis requires further verification.

Key words:
cardiovascular risk – LDL cholesterol


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Angiology Diabetology Internal medicine Cardiology General practitioner for adults
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