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State of the Intestinal Microbiome and COVID-19 Infection −⁠ Possible Correlations

16. 2. 2021 Source: GI, colic and microbiome

Some patients infected with the SARS-CoV-2 virus exhibit gastrointestinal symptoms, including diarrhea, during the course of COVID-19. Current knowledge suggests that COVID-19 symptoms are related, among other things, to the intestinal microbiome. Could the use of probiotics therefore act as a prevention of this disease or its more severe course?

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Safety Profile of Antiemetic Therapy in Patients Preparing for Hematopoietic Stem Cell Transplantation

An observational study conducted at a university clinic in Barcelona investigated the safety of the fixed combination of palonosetron and netupitant in patients preparing for hematopoietic stem cell…
15. 2. 2021 Source: Antiemetic Therapy
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Intravenous Fixed Combination NEPA in the Prevention of Chemotherapy-Induced Vomiting

Summary data from several studies were used by the authors of the following analysis to evaluate the efficacy of the intravenous and oral forms of the fixed combination NEPA (netupitant/fosnetupitant…
15. 2. 2021 Source: Antiemetic Therapy
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Brigatinib vs. Crizotinib in the Treatment of ALK-Positive NSCLC –⁠ Results of the Second Interim Analysis of the ALTA-1L Study

The anaplastic lymphoma kinase inhibitor brigatinib demonstrated superiority over crizotinib in the first interim analysis of the ALTA-1L study in terms of progression-free survival and improvement…
15. 2. 2021 Source: Non-Small Cell Lung Cancer
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Good Efficacy of Brigatinib After Failure of 2nd Generation ALK Inhibitors

Brigatinib is commonly used in the treatment of ALK-positive non-small cell lung cancer (NSCLC) in the 2nd line after progression on a 1st-generation ALK inhibitor, crizotinib. American scientists in…
15. 2. 2021 Source: Non-Small Cell Lung Cancer
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Does olaparib improve overall survival in patients with recurrent ovarian cancer and BRCA mutation?

Olaparib, a poly(ADP-ribose) polymerase (PARP) enzyme inhibitor, in tablet form is indicated, among other things, for the maintenance treatment of adult patients with platinum-sensitive recurrent…
13. 2. 2021 Source: Ovarian and Breast Cancer
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Trazodone in the Treatment of Depressive Disorder –⁠ A Case Study

Presented by MUDr. Sylva Racková, Ph.D. Psychiatric Clinic, Plzeň
12. 2. 2021 Source: Depression and Anxiety
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Hydrotherapy in the Treatment of Non-Healing Wounds

For the treatment of wounds, it is crucial how they are managed during the cleaning and granulation phases. For most non-healing wounds, so-called Hydrotherapy (treatment with hydroresponsive…
10. 2. 2021 Source: Wound Healing
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International Recommendations for COVID-19 Vaccination in People with Bleeding Disorders

At the end of December 2020, international guidelines for COVID-19 vaccination in people with bleeding disorders were published on the World Federation of Hemophilia (WFH) website. We present a basic…
8. 2. 2021 Source: Hemophilia
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COVID-19: Specifics of Care for Individuals with Congenital Bleeding Disorders

The COVID-19 pandemic has significantly impacted nearly all medical fields. Alongside direct care focused on seriously ill patients, the pandemic also affects the care of chronic patients, including…
8. 2. 2021 Source: Hemophilia
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Invasive Pulmonary Aspergillosis –⁠ A Common Accompanying Infection in Patients with Severe or Critical Course of COVID-19

Findings based on a literature review conducted and published in September 2020 show the occurrence of invasive pulmonary aspergillosis (IPA) in 19.6–33.3% of patients with a severe or critical…
8. 2. 2021 Source: Anti-Infectives
Starší pacient

Trifluridine/Tipiracil in the 3rd Line Treatment of mCRC −⁠ Case Study

The following case study describes the treatment of a patient with metastatic colorectal cancer (mCRC) and the benefits of trifluridine/tipiracil within the therapeutic algorithm.
3. 2. 2021 Source: Treatment of Gastrointestinal Carcinomas
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Atectura® and Enerzair®: new fixed dual and triple combination in the treatment of bronchial asthma

In mid-2020, the European Commission approved two new fixed combinations of drugs by Novartis for patients with uncontrolled asthma –⁠ the dual combination Atectura® (LABA+ICS) and the triple…
28. 1. 2021 Source: Asthma under control
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Recent Advances in Physiotherapy for Hemophiliacs

Physiotherapy specifically focuses on movement and the movement potential of the individual, with the purpose of restoring or maintaining maximum mobility and functional abilities throughout life.…
28. 1. 2021 Source: Hemophilia with Movement
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Turoctocog Alfa Pegol with Extended Half-Life in the Treatment of Severe Hemophilia A

GlycoPEGylated recombinant factor VIII (rFVIII) with an extended half-life, turoctocog alfa pegol, has demonstrated prophylactic efficacy in patients with severe hemophilia A aged over 12. This…
28. 1. 2021 Source: Hemophilia with Movement
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