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Chronic lymphocytic leukemia (CLL)

Venetoclax Treatment Strategies in Patients with CLL

20. 4. 2022 Source: Chronic Lymphocytic Leukemia

One of the new targeted preparations in the treatment of chronic lymphocytic leukemia (CLL) is the Bcl-2 inhibitor venetoclax. Its significant advantage is the potential to achieve deep remission, including undetectable minimal residual disease (MRD). Unlike other targeted drugs, it can be administered for a limited period of time. The following text presents current data from clinical trials and information on the strategy of selecting and sequencing targeted CLL treatment.

Onkology1

Efficacy of Lorlatinib in Patients with ROS1-Positive NSCLC in Clinical Practice

Interesting real-world data have been brought by a study on the efficacy of lorlatinib in patients with non-small cell lung cancer (NSCLC) with a mutation in the ROS1 gene.
20. 4. 2022 Source: Genetic Profile and Treatment of NSCLC
Muž_dýchání_lékařka

Interactive Case Study: AATD –⁠ Alpha-1-Antitrypsin Deficiency

We present a case study of a man who was 41 years old at the time of his first contact with a pulmonary doctor. He came with symptoms of allergic seasonal rhinoconjunctivitis, proven sensitivity to…
19. 4. 2022 Source: Deficiency of Alpha-1-Antitrypsin
Streptococcus mutans2

Probiotics as a Means to Reduce the Incidence of Streptococcus Mutans

Data from a prospective study examining the effects of probiotics on the oral microbiome show the ability of orally administered probiotics to reduce the incidence of Streptococcus mutans and also…
19. 4. 2022 Source: GI, colic and microbiome
Treatment of Knee Pain and Arthritis

Long-term Efficacy of Targeted Therapy for Axial Spondyloarthritis

How does etanercept fare in the long-term treatment of early axial spondyloarthritis (axSpA)? Data from over 10 years of follow-up in patients with both radiographic and non-radiographic forms of…
19. 4. 2022 Source: Arthritis
léky na srdce

Comparison of Cardiovascular Effects of Sitagliptin and Empagliflozin

Cardiovascular (CV) diseases remain the leading cause of death among patients with type 2 diabetes (T2D). Reducing the incidence of macrovascular CV events in diabetics requires more than just…
19. 4. 2022 Source: Diabetes
prim Ondrejka

Prim. MUDr. Gustáv Ondrejka: Biological treatment of asthma eliminates the need for systemic corticotherapy

Despite advances in the therapy of bronchial asthma, a portion of patients still do not achieve the desired control of the disease. The introduction of biological treatment marked a significant…
18. 4. 2022 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation
medicínská studie 2

Prophylaxis with Rurioctocog Alfa Pegol in Severe Hemophilia A

Rurioctocog alfa pegol represents a modern modality for the treatment of hemophilia from the group of factors with an extended half-life. The authors of a systematic review and meta-analysis…
14. 4. 2022 Source: Hemophilia
starší muž na neurologii

Impact of Prophylaxis on Reducing the Risk of Neurological Problems Associated with Bleeding in Hemophilia A

Bleeding can also cause complications in the nervous system of hemophiliacs. The authors of the work presented below discuss the significance of prophylactic administration of factor VIII coagulation…
14. 4. 2022 Source: Hemophilia
American Society of Hematology

Brief from ASH 2021: News and Advances in CLL Treatment

The summary from the first day of the 63rd American Society of Hematology (ASH) Congress in Atlanta in December 2021 brought several new advancements in the treatment of chronic lymphocytic leukemia…
12. 4. 2022 Source: Chronic Lymphocytic Leukemia
diabetes mellitus 5

Albuminuria as a Risk Factor for Cardiovascular Events and Mortality in Patients with Type 2 Diabetes Without Apparent Cardiovascular Disease

Albuminuria in patients with type 2 diabetes is associated with a higher risk of cardiovascular (CV) events and higher mortality. However, this association has not been thoroughly investigated in…
12. 4. 2022 Source: Diabetes
psoriaza za uchom

Bimekizumab –⁠ Higher Chance of Complete Skin Healing in Moderate to Severe Psoriasis?

In August 2021, the European Medicines Agency (EMA) approved bimekizumab (Bimzelx LP) as the first psoriasis treatment that selectively and directly inhibits interleukins IL-17A and IL-17F. It is…
12. 4. 2022 Source: Psoriasis
injekce v těhotenství

Benefits of Enoxaparin Prophylaxis in Pregnancy and Postpartum

Study results suggest that the use of low molecular weight heparins during pregnancy could lead to better outcomes for women with thrombophilia and recurrent miscarriages. A group of authors from…
11. 4. 2022 Source: Thromboprophylaxis
nadvaha doktor

Impact of Combined Oral Contraceptives on Body Weight

A relatively recent study investigated changes in the average body weight of women who used combined oral contraceptives with 30 μg ethinylestradiol (EE) and 3 mg drospirenone (DRSP) or 30 μg EE and…
10. 4. 2022 Source: Oral Contraception
sepse

Monocyte Distribution Width as an Early Indicator of Sepsis in ICU Patients

Authors of a Franco-Spanish study propose using the monocyte distribution width along with leukocyte count as a screening test to refine the early diagnosis of sepsis in intensive care unit (ICU)…
9. 4. 2022 Source: Because
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