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Innovative Form of Levothyroxine Ensures Accurate Dosing for Patients

8. 6. 2022 Source: Thyroid Disorders

In the treatment of hypothyroidism, precise dosing of replacement therapy is critical. An innovative formulation of levothyroxine has been developed to meet the updated, stricter standards of regulatory authorities, thereby ensuring the desired therapeutic effect.

Levothyroxine Substitution Depending on Patient Genotype

Careful titration of hormone dose leads to optimal dosing of replacement therapy for hypothyroidism. The authors of a cross-sectional study published in the Endocrine Journal examined the impact of polymorphisms...

7. 6. 2022 Source: Thyroid Disorders

Safety and Efficacy of Combination Therapy for Allergic Rhinitis Compared to Monotherapies and Placebo

Combination therapy of antihistamine and corticosteroid is a promising alternative for patients suffering from seasonal allergic rhinitis. A phase II clinical study aimed to determine the effective…

7. 6. 2022 Source: Life Without Allergic Rhinitis

Allergic Rhinitis in the General Practitioner’s Office: How to Proceed in Primary Care?

Up to 60% of the population has a genetic predisposition to allergic disease. Diagnosis and therapy of allergic conditions are therefore very common topics in primary care. How should we proceed…

7. 6. 2022 Source: Life Without Allergic Rhinitis

Efficacy and Safety of Etanercept in the Therapy of Arthritis

A review by experts from Genoa, Italy, focused on the available knowledge regarding the efficacy and safety of etanercept in the treatment of inflammatory rheumatic diseases.

7. 6. 2022 Source: Arthritis

Metformin in Pregnancy and Its Safety Profile

In Finland, a comprehensive analysis of data from the national registry was conducted to assess whether exposure to metformin during intrauterine development is associated with an increased risk of long-term...

6. 6. 2022 Source: Modern Treatment of Diabetes

MS in Children –⁠ An Overlooked Sister of Adult Diseases?

Multiple sclerosis is not just an adult disease. How common is it in children and how have current therapeutic possibilities advanced for this population both in our country and around the world?

6. 6. 2022 Source: Multiple Sclerosis

Safety and Efficacy of Bimekizumab Self-Administration in Psoriasis Patients

Patient adherence to regular administration of biologic therapy is crucial for its effectiveness. The studies presented below evaluated self-administration of the humanized monoclonal antibody…

3. 6. 2022 Source: Psoriasis

Efficacy and Safety of Teriflunomide in the Treatment of Multiple Sclerosis in Children –⁠ Results of the TERIKIDS Study

Therapeutic options for multiple sclerosis in the pediatric population are limited. However, in June 2021, teriflunomide was approved for the treatment of relapsing-remitting multiple sclerosis…

1. 6. 2022 Source: Multiple Sclerosis

Cost-Effectiveness of Eletriptan in Acute Migraine Treatment

Even in a market dominated by generics, eletriptan 40 mg is among the most clinically effective and cost-efficient triptans for the acute treatment of migraine attacks. This was demonstrated by a…

1. 6. 2022 Source: Treatment of Severe Migraine

Doc. Petr Dulíček: Physical activity in hemophiliacs? Today it is a reality -⁠ just don't be afraid!

Thanks to modern treatment, the lives of hemophiliacs are becoming more active. Patients today can engage in most sports activities. On the contrary, avoiding physical activity carries the risk of…

30. 5. 2022 Source: Hemophilia with Movement

Prevalence and Clinical Impact of Overweight and Obesity in the Hemophilia Population

Obesity is classified as a lifestyle disease with increasing prevalence and a rising contribution to morbidity and mortality in the general population. The epidemic of overweight and obesity also does...

30. 5. 2022 Source: Hemophilia with Movement

Tofacitinib Helps Restore Intestinal Epithelial Barrier

The Janus kinase inhibitor (JAKi) tofacitinib was relatively recently approved for the treatment of ulcerative colitis, but its effect on the intestinal epithelium remains a subject of research. The…

30. 5. 2022 Source: Intestinal Inflammations

Safety and Efficacy of Long-term Tofacitinib Therapy in Patients with Active Psoriatic Arthritis –⁠ Interim Results of the OPAL Balance Study

Tofacitinib is a potent selective inhibitor of the Janus kinase (JAK) family indicated for the treatment of active psoriatic arthritis in adult patients. The efficacy and safety of tofacitinib in…

30. 5. 2022 Source: Arthritis

Cardiovascular Safety of Tofacitinib in Real-World Clinical Practice –⁠ Results of the STAR-RA Study

Recent results from the ORAL Surveillance clinical trial have raised concerns about the cardiovascular adverse effects of tofacitinib in patients with rheumatoid arthritis. A comprehensive analysis…

29. 5. 2022 Source: Arthritis

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