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Nirmatrelvir/ritonavir reduces the risk of hospitalization for COVID-19 even in the era of predominant omicron subvariants BA.4 and BA.5

16. 10. 2023 Source: COVID-19

One of the first studies to evaluate the efficacy of nirmatrelvir/ritonavir in non-hospitalized patients with COVID-19 infection during the period of predominant omicron variants including subvariants BA.4 and BA.5 has provided real-world data confirming the position of this antiviral in the first line of treatment for patients with mild to moderately severe SARS-CoV-2 infection and a high risk of severe disease.

Effectiveness of the Sonicare For Kids Toothbrush in Preschool Children

A comparative study conducted as part of a graduation thesis in the field of Certified Dental Hygienist offers a comparison of the cleaning effectiveness of a manual toothbrush and a sonic toothbrush…

15. 10. 2023 Source: Dental Care

Prof. Martina Koziar Vašáková: In the spotlight of pulmonologists are now lung screening and chronic lung diseases

As part of a series of interviews with the heads of professional societies on the topic of hot topics 2023, we speak with the chairwoman of the Czech Pneumological and Phthiseological Society of the…

15. 10. 2023 Source: Respiratory Health

Benefit of Adding Panitumumab to Maintenance Therapy in mCRC with Non-mutated RAS Oncogene

PANAMA was the first randomized study evaluating the addition of an anti-EGFR antibody to maintenance therapy with fluorouracil and folic acid (FU/FA) in patients with previously untreated metastatic…

14. 10. 2023 Source: Colorectal Cancer

Tapentadol Hydrochloride in Clinical Practice –⁠ To Whom, When, How, and Why?

Thanks to its specific properties, tapentadol hydrochloride ranks among the most effective opioids for managing chronic non-cancer pain. Unlike most opioids, it also exhibits an analgesic effect in…

12. 10. 2023 Source: Updates in Pain Treatment

What a Decade of Experience with Tapentadol Hydrochloride in Pain Treatment Has Shown

In an interview with Dr. Marek Hakl, Ph.D., from the Brno Pain Treatment Center, we focus on the role of tapentadol hydrochloride in the treatment of chronic pain. We discuss, among other things, its…

12. 10. 2023 Source: Updates in Pain Treatment

Long-term Benefit of Sotorasib for Survival of Patients with Pre-treated Advanced/Metastatic NSCLC with G12C Mutation of KRAS Oncogene

Sotorasib is indicated as monotherapy for advanced non-small-cell lung cancer (NSCLC) with the KRAS^G12C gene mutation, if there has been progression after ≥ 1 prior line of systemic therapy. The…

10. 10. 2023 Source: Lung Cancer

INFOGRAPHIC: Post-Induction Therapy for AML –⁠ Current Guidelines

What are the recommended therapeutic modalities for consolidation and maintenance therapy of acute myeloid leukemia (AML) in patients over 60 years of age? We present a clear therapeutic algorithm…

10. 10. 2023 Source: Acute Myeloid Leukemia

Oral Azacitidine After Achieving Remission in AML Improves Survival and Does Not Worsen Quality of Life

Orally administered azacitidine as maintenance therapy in patients with acute myeloid leukemia (AML) after achieving remission provides a favorable effect in terms of fatigue and improving…

10. 10. 2023 Source: Acute Myeloid Leukemia

Improvement of Executive Functions in Therapy of Dravet Syndrome with Fenfluramine in Preschool Children

Dravet syndrome is a rare genetic progressive epileptic encephalopathy that is usually accompanied by intellectual and behavioral disorders. Many children with this syndrome also struggle with…

10. 10. 2023 Source: Rare Diseases in Neurology

Myasthenia Gravis and Unmet Patient Needs –⁠ Data from Clinical Practice

Myasthenia gravis (MG) is a rare, chronic, disabling, unpredictable, and potentially life-threatening autoimmune neuromuscular disease. There is still a lack of sufficient data from real clinical…

10. 10. 2023 Source: Rare Diseases in Neurology

Definition and Classification of Chronic Kidney Disease According to KDIGO

We provide a brief overview of the definition and classification of chronic kidney disease based on the updated KDIGO (Kidney Disease: Improving Global Outcomes) clinical practice guidelines from 2012...

9. 10. 2023 Source: Cardiovascular Risks

Side Effects of Antipsychotics and Patient Preferences in the Treatment of Schizophrenia

Although a number of antipsychotics are currently available, many patients still suffer from unpleasant side effects associated with the treatment of schizophrenia. To determine how individuals with…

9. 10. 2023 Source: Modern Treatment of Schizophrenia

Physical Activity in Young Men with Hemophilia A

What may influence the inclusion of physical activity in the lifestyle of individuals with hemophilia? This was the focus of a Norwegian study published in the journal Haemophilia.

6. 10. 2023 Source: Hemophilia with Movement

N9-GP in Previously Treated Pediatric Patients with Hemophilia B –⁠ Extended Follow-up

An analysis of extended treatment with nonacog alfa pegol (N9-GP) in pediatric patients with hemophilia B evaluated the long-term safety and effectiveness of this prophylactic modality.

4. 10. 2023 Source: Hemophilia with Movement

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