News
Stabilization of Transthyretin and Long-term Survival of Patients with Cardiac Amyloidosis
Tafamidis is used in the therapy of transthyretin amyloid cardiomyopathy (ATTR-CM), which has proven its benefit in the ATTR-ACT clinical study. The results of its open-label extension study show that early diagnosis and prompt initiation of therapy are crucial.
HVD 2023: Cervical Cancer May Be the First Eliminated Malignancy. What Paths Will Lead to This Goal in the Czech Republic?
Cervical cancer is the 3rd most common cancer among women aged 15–44. Annually, it is diagnosed in 750–800 women in our country, and every 29 hours, one woman dies from it in the Czech Republic.…
Drops with Liposomal Ozonized Oil Reduce Ocular Microbial Burden Before Cataract Surgery
The periocular zone and conjunctiva are characterized by high microbial activity. Therefore, it is important to reduce this bacterial burden as part of preoperative prophylaxis before surgery to…
Post hoc Analysis of the FRAME Study – Romosozumab in the Treatment of Osteoporosis in the European Population
An interesting finding from the FRAME study, which evaluated the treatment of postmenopausal women with osteoporosis using romosozumab, was the significant differences in fracture incidence among…
Romosozumab vs. Teriparatide in Sequential Treatment of Osteoporosis in Women with a History of Fracture
The STRUCTURE study observed the effect of romosozumab and teriparatide on bone density in postmenopausal women with osteoporosis transitioning from bisphosphonate treatment over a 12-month period.
How Important is the Time Factor in the Treatment of Heart Failure?
Current guidelines emphasize the importance of early diagnosis and immediate treatment for patients with heart failure (HF). These patients are most vulnerable immediately after the decompensation of…
Transthyretin Amyloidosis in Patients with Carpal Tunnel Syndrome
Carpal tunnel syndrome is considered a warning sign for cardiac amyloidosis. Amyloid deposits are often found in the tenosynovial material removed during surgery. However, the prevalence of…
Inhibition of Mutated KRAS Protein as a New Option for Targeted Treatment of Non-Small Cell Lung Cancer
RAS proteins are molecular switches for several intracellular signaling pathways. Their dysfunction due to mutation leads to the development and progression of malignant diseases such as colon or…
MUDr. Tomáš Mašek: In the prevention of hemorrhoids, more use of venopharmaceuticals is needed
While in the past the diagnosis of hemorrhoids was inextricably linked to traditional surgical solutions, today - thanks to the expansion of the indication for venopharmaceuticals for this condition…
Balance and Rehabilitation – Firm on the Ground Even with Multiple Sclerosis
A large portion of patients with multiple sclerosis (MS) suffer from balance disorders. What are the options for non-pharmacological therapy for these issues according to the latest studies?
Instead of NSAIDs, consider combining paracetamol with a weak opioid
Chronic non-cancer pain is a problem that primary care physicians encounter on a daily basis. In the following interview with general practitioner MUDr. Michaela Wichová, we discuss how to approach a…
Fixed combination tramadol/paracetamol as an effective and safe option for long-term pain treatment even in polymorbid patients
Combined analgesics were historically recommended exclusively for the treatment of acute or postoperative pain, mainly due to the risk of individual components which, although potentiated their…
Pharmacological Profile of Mavacamten and Key Studies of Its Use in HCM Treatment
A new addition to the treatment options for hypertrophic cardiomyopathy, approved for use in European Union countries in June 2023, is the selective reversible cardiac myosin inhibitor mavacamten.…
INFOGRAPHIC: Diagnosis and Monitoring of Patients with Hypertrophic Cardiomyopathy – Current Guidelines
What examinations should be conducted when suspecting hypertrophic cardiomyopathy, a hereditary disease caused by mutations in genes encoding cardiac muscle proteins? What is the subsequent procedure…
Neutropenia with Thrombocytopenia after Alemtuzumab? − Case Report
Early neutropenia with thrombocytopenia is not a common side effect of alemtuzumab. However, the patient in the following case report by Italian colleagues was affected. What was the outcome?