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amyloid

Stabilization of Transthyretin and Long-term Survival of Patients with Cardiac Amyloidosis

20. 11. 2023 Source: Amyloidosis

Tafamidis is used in the therapy of transthyretin amyloid cardiomyopathy (ATTR-CM), which has proven its benefit in the ATTR-ACT clinical study. The results of its open-label extension study show that early diagnosis and prompt initiation of therapy are crucial.

karcinom

HVD 2023: Cervical Cancer May Be the First Eliminated Malignancy. What Paths Will Lead to This Goal in the Czech Republic?

Cervical cancer is the 3rd most common cancer among women aged 15–44. Annually, it is diagnosed in 750–800 women in our country, and every 29 hours, one woman dies from it in the Czech Republic.…
15. 11. 2023 Source: Regular Vaccination
oko

Drops with Liposomal Ozonized Oil Reduce Ocular Microbial Burden Before Cataract Surgery

The periocular zone and conjunctiva are characterized by high microbial activity. Therefore, it is important to reduce this bacterial burden as part of preoperative prophylaxis before surgery to…
14. 11. 2023 Source: Treatment of Glaucoma
studie_osteoporoza

Post hoc Analysis of the FRAME Study –⁠ Romosozumab in the Treatment of Osteoporosis in the European Population

An interesting finding from the FRAME study, which evaluated the treatment of postmenopausal women with osteoporosis using romosozumab, was the significant differences in fracture incidence among…
14. 11. 2023 Source: Osteoporosis – Trends in Sequential Therapy
kost

Romosozumab vs. Teriparatide in Sequential Treatment of Osteoporosis in Women with a History of Fracture

The STRUCTURE study observed the effect of romosozumab and teriparatide on bone density in postmenopausal women with osteoporosis transitioning from bisphosphonate treatment over a 12-month period.
14. 11. 2023 Source: Osteoporosis – Trends in Sequential Therapy
srdce

How Important is the Time Factor in the Treatment of Heart Failure?

Current guidelines emphasize the importance of early diagnosis and immediate treatment for patients with heart failure (HF). These patients are most vulnerable immediately after the decompensation of…
13. 11. 2023 Source: Heart Failure
KARPÁLNI TUNEL

Transthyretin Amyloidosis in Patients with Carpal Tunnel Syndrome

Carpal tunnel syndrome is considered a warning sign for cardiac amyloidosis. Amyloid deposits are often found in the tenosynovial material removed during surgery. However, the prevalence of…
10. 11. 2023 Source: Amyloidosis
plice

Inhibition of Mutated KRAS Protein as a New Option for Targeted Treatment of Non-Small Cell Lung Cancer

RAS proteins are molecular switches for several intracellular signaling pathways. Their dysfunction due to mutation leads to the development and progression of malignant diseases such as colon or…
9. 11. 2023 Source: Lung Cancer
TomasMasek

MUDr. Tomáš Mašek: In the prevention of hemorrhoids, more use of venopharmaceuticals is needed

While in the past the diagnosis of hemorrhoids was inextricably linked to traditional surgical solutions, today -⁠ thanks to the expansion of the indication for venopharmaceuticals for this condition…
7. 11. 2023 Source: Venous Insufficiency
rehabilitace

Balance and Rehabilitation –⁠ Firm on the Ground Even with Multiple Sclerosis

A large portion of patients with multiple sclerosis (MS) suffer from balance disorders. What are the options for non-pharmacological therapy for these issues according to the latest studies?
1. 11. 2023 Source: Multiple Sclerosis
MW

Instead of NSAIDs, consider combining paracetamol with a weak opioid

Chronic non-cancer pain is a problem that primary care physicians encounter on a daily basis. In the following interview with general practitioner MUDr. Michaela Wichová, we discuss how to approach a…
1. 11. 2023 Source: Updates in Pain Treatment
bolest_muž

Fixed combination tramadol/paracetamol as an effective and safe option for long-term pain treatment even in polymorbid patients

Combined analgesics were historically recommended exclusively for the treatment of acute or postoperative pain, mainly due to the risk of individual components which, although potentiated their…
1. 11. 2023 Source: Updates in Pain Treatment
hypertrofická kardiomyopatie

Pharmacological Profile of Mavacamten and Key Studies of Its Use in HCM Treatment

A new addition to the treatment options for hypertrophic cardiomyopathy, approved for use in European Union countries in June 2023, is the selective reversible cardiac myosin inhibitor mavacamten.…
1. 11. 2023 Source: Hypertrophic Cardiomyopathy (HCM)
kardiomyopatie_léky

INFOGRAPHIC: Diagnosis and Monitoring of Patients with Hypertrophic Cardiomyopathy –⁠ Current Guidelines

What examinations should be conducted when suspecting hypertrophic cardiomyopathy, a hereditary disease caused by mutations in genes encoding cardiac muscle proteins? What is the subsequent procedure…
1. 11. 2023 Source: Hypertrophic Cardiomyopathy (HCM)
mozek

Neutropenia with Thrombocytopenia after Alemtuzumab? −⁠ Case Report

Early neutropenia with thrombocytopenia is not a common side effect of alemtuzumab. However, the patient in the following case report by Italian colleagues was affected. What was the outcome?
1. 11. 2023 Source: Multiple Sclerosis
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