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Targeted DNA Sequencing Helps Find Targeted Therapy for Patients with NSCLC

25. 5. 2020 Source: Genetic Profile and Treatment of NSCLC

Gene sequencing has become a key tool in deciding the treatment for patients with non-small cell lung cancer (NSCLC). At a university in Seoul, South Korea, a retrospective analysis of the benefits of targeted genetic testing in real clinical practice was conducted.

Hypnotics in the Therapy of Insomnia (Not Only) in the Elderly

Problems with insomnia make up a significant part of the subjective complaints, especially of older patients in our clinics. Up to 1/3 of the population may suffer from chronic insomnia symptoms, and…

25. 5. 2020 Source: Geriatric Patient

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Safety and efficacy of dabigatran and other NOACs compared with warfarin in patients with atrial fibrillation –⁠ results of a large long-term prospective study

Anticoagulant therapy is key in the prevention of strokes in patients with atrial fibrillation. Until the introduction of new oral anticoagulants (NOACs), warfarin was the first-choice drug for these…

25. 5. 2020 Source: Anticoagulant Treatment

Primum non nocere applies not only in medicine: an ecological look at inhalers

According to estimates from the World Health Organization (WHO), around 65 million people worldwide suffer from mild to moderate forms of chronic obstructive pulmonary disease (COPD). The cornerstone…

25. 5. 2020 Source: COPD

Effect of Beta-Blockers on Glucose Metabolism and Their Use in Diabetics with Hypoglycemic Episodes

Beta-blockers, through their mechanism of action, can lead to the deepening or direct initiation of both hypoglycemia and hyperglycemia. The study presented below, published last year, evaluated the…

21. 5. 2020 Source: Cardiovascular Continuum

Trazodone with Extended Release Improves Patient Compliance

Since 2015, the antidepressant trazodone is available in the Czech Republic in a controlled-release formulation. A sufficiently high plasma level for 24 hours without fluctuation allows for…

20. 5. 2020 Source: Depression and Anxiety

Ixekizumab administered for 5 years demonstrated high efficacy and a favorable safety profile in patients with moderate to severe psoriasis

Ixekizumab is a recombinant humanized monoclonal antibody against interleukin 17A, indicated for the treatment of moderate to severe plaque psoriasis and psoriatic arthritis. At the 24th World…

19. 5. 2020 Source: Biological Treatment

Incidence of Thromboembolic Disease During Military Operations –⁠ Results of a 10-Year Review

In contemporary armed conflicts, limb injuries account for more than half of all injuries. In addition to the characteristically high incidence of infectious complications, injuries associated with…

18. 5. 2020 Source: Prevention of Thrombosis in Surgery

Comparison of Three Thromboprophylactic Regimens in Patients Post Pancreatic Surgery

Post-pancreatectomy bleeding and thromboembolic disease are among the serious complications of pancreatic surgeries. The aim of the study published last year in the British Journal of Surgery was to…

18. 5. 2020 Source: Prevention of Thrombosis in Surgery

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Do Beta-Blockers Increase the Risk of Hypoglycemia in Patients with Diabetes and Atherosclerosis?

Given that a large portion of patients with diabetes have proven cardiovascular disease, several clinical studies or their subsequent analyses address the effects of beta-blockers in these patients.…

18. 5. 2020 Source: Cardiovascular Continuum

Impact of Body Mass Index on Survival and Treatment Outcomes of Metastatic Colorectal Cancer

A pooled analysis of 25 studies with patients in the first line of treatment for metastatic colorectal cancer (mCRC) evaluated the prognostic and predictive significance of body mass index (BMI).…

17. 5. 2020 Source: Colorectal Cancer

Testing RAS Gene Mutations in Patients with Colorectal Cancer

Correct identification of the RAS oncogene variant is crucial for deciding the treatment of patients with colorectal cancer. Information on the prevalence of individual RAS gene mutations varies…

17. 5. 2020 Source: Colorectal Cancer

Reimbursement vs. Indication: Are They Clashing in Alzheimer's Disease?

Data from clinical trials and recommended procedures do not always align with insurance reimbursement criteria. Is this the case with Alzheimer's disease treatment?

17. 5. 2020 Source: Cognitive in the treatment of Alzheimer's disease

Does Dosage Frequency Matter for Adherence to Anticholinergic Treatment in Patients with COPD?

A study by Spanish authors compared the adherence of patients with chronic obstructive pulmonary disease (COPD) to anticholinergic treatment administered once every 12 hours and once every 24 hours.

15. 5. 2020 Source: Treatment of Asthma and COPD

Potential, Benefits and Proper Use of Probiotics in the Treatment of Acute Gastroenteritis in Children

Clinical studies and experiences from clinical practice have shown the benefits of administering probiotics in the treatment of acute gastroenteritis in children. Pediatrician Dr. Natália Szitányi…

15. 5. 2020 Source: GI, colic and microbiome

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