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News Meta-analysis of Efficacy and Safety of Antidiabetics in Treating Gestational DM

What efficacy and safety do insulin, metformin, or the sulfonylurea derivative glibenclamide (glyburide) offer in lowering glucose levels in women with gestational diabetes? The authors of a meta-analysis of randomized controlled trials used a probabilistic model –⁠ a Bayesian network –⁠ to answer this question.

Source: Modern Treatment of Diabetes 13. 9. 2023

News Current and Future Possibilities for Influencing Immune Thrombocytopenia

The possibilities for treating immune thrombocytopenia (ITP) are quite broad today, with a major advancement for many patients being the advent of thrombopoietin receptor agonists. However, for some patients, optimal treatment is still not available, and their hope lies in further research.

Source: Immune Thrombocytopenia 16. 5. 2022

Články časopisu Current treatment options for hepatocellular carcinoma

Author of the article: MUDr. Kubala Eugen Source: Klinická onkologie | Supplementum 3/2020 31. 10. 2020

Články časopisu Efficiency of Robot-assisted Therapy through the Device Armeo Spring in Patients after Stroke in Acute Phase of Early Rehabilitation

Author of the article: R. Bocanová, T. Gueye, O. Švestková, A. Oktábcová Source: Rehabilitation & Physical Medicine | 3/2018 23. 8. 2018

News Comparison of Enoxaparin and Unfractionated Heparin in Hospitalized Patients in Terms of Clinical and Cost Effectiveness

Thromboembolic disease represents one of the severe complications in hospitalized patients. Low molecular weight and unfractionated heparin are most commonly used during hospitalization as part of pharmacological thromboprophylaxis. An extensive study conducted in the United States evaluated the clinical and cost-effectiveness and safety of both therapy modalities in hospitalized patients at risk of thromboembolic disease.

Source: Thromboprophylaxis 31. 3. 2022

News Metamizole in Pain Management for Patients with Subarachnoid Hemorrhage

A study by Czech authors from the University Hospital St. Anna in Brno, recently published in the British Journal of Neurosurgery, evaluated analgesic treatment in patients with subarachnoid hemorrhage. The use of metamizole as the primary analgesic was associated with a significantly lower risk of adverse clinical outcomes at 2 weeks and 6 months compared to other non-opioid and opioid analgesics.

Source: Analgesia 10. 5. 2023

News Quality of Life of Patients on Adjuvant Treatment for HER2-Positive Breast Cancer

The KATHERINE clinical trial demonstrated that adjuvant therapy with trastuzumab emtansine compared to trastuzumab significantly improves invasive disease-free survival in patients with HER2-positive early breast cancer and residual invasive disease after prior treatment. A post hoc analysis of this study was published in the journal Cancer, focusing on patient-reported outcomes related to quality of life during and after treatment.

Source: Breast Carcinoma 28. 5. 2020

Články časopisu Advances in the therapy of small cell lung cancer

Author of the article: D. Vrána Source: Klinická onkologie | Supplementum 1/2021 27. 5. 2021

News Overlap of SGLT2 Inhibitors from Diabetology to Cardiology

As recent research shows, one of the modern groups of antidiabetic drugs -⁠ SGLT2 inhibitors, also known as gliflozins -⁠ brings benefits not only in diabetology but also in cardiology and nephrology. It has been confirmed that representatives of this class of drugs prolong patients' lives, reduce the incidence of major cardiovascular (CV) events and the risk of heart failure (HF), and improve renal function. A recently published study additionally indicates that the CV benefit of empagliflozin is independent of the number of compensated CV risk factors and manifests within the first 3 months of treatment.

Source: Diabetes 29. 10. 2021

News Clinical Significance of Smaller Gaps Between Strengths of Levothyroxine Preparations in the Treatment of Hypothyroidism

Many levothyroxine preparations have relatively large intervals between doses (25 µg, 50 µg, and 75 µg), creating obstacles for some patients to achieve an optimal maintenance dose. The availability of tablets that allow for dosing in between these values facilitates precise and effective titration of levothyroxine doses, especially at the lower end of the spectrum.

Source: Thyroid Disorders 23. 2. 2024

News How Does the Long-Term Effect of Beta Blocker Use Affect Clinical Outcomes in Patients After Myocardial Infarction?

In patients after myocardial infarction (MI), beta blockers (BB) still hold an important place in secondary prevention according to recommended procedures. However, the question could be their long-term effect on clinical outcomes, as different results can be found in the literature –⁠ this fact led the authors of the work cited below to perform a systematic review and meta-analysis of studies dedicated to this issue.

Source: Cardiovascular Continuum 25. 10. 2023

News Progress on Lorlatinib –⁠ What's Next?

Lorlatinib is currently mainly used in the 2nd and later lines of treatment for non-small cell lung cancer (NSCLC) with ALK gene rearrangement. Clinical research is now focusing on the question of how to proceed with patients who experience disease progression during lorlatinib treatment in later lines of therapy. It seems that one of the options might actually be to do nothing –⁠ to continue with lorlatinib.

Source: Genetic Profile and Treatment of NSCLC 17. 5. 2022

News Reversal of Dabigatran Effects with Idarucizumab in Patients Requiring Urgent Procedures: Subanalysis of the RE-VERSE AD Study

The effect of idarucizumab as a reversal agent in patients treated with dabigatran in situations requiring urgent surgery or other invasive procedures was evaluated in a subanalysis from the RE-VERSE AD study published in 2021.

Source: Anticoagulant Treatment 18. 11. 2021

News Therapy with Cyclosporine in the Context of the Coronavirus Pandemic

The rapid spread of the SARS-CoV-2 virus and the associated COVID-19 disease pandemic raises concerns about possible risks associated with immunosuppressive treatment of autoimmune diseases. Specifically, does the use of cyclosporine increase the risk of infection, or does it act protectively?

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 14. 4. 2021

Články časopisu Gynecologic robotic surgery and our initial experience

Author of the article: R. Pilka, P. Dzvinčuk Source: Česká gynekologie | 6/2010 20. 12. 2010