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News Impact of Candesartan on Achieving Remission in Patients with Active IgA Nephropathy
IgA nephropathy is the most common glomerulonephritis worldwide and in the Czech Republic. The effect of candesartan (an angiotensin receptor blocker) on the remission of active IgA nephropathy in patients treated with steroid pulses and tonsillectomy was investigated by the randomized study presented below.
News Impact of Lifestyle on the Benefit of Pharmacotherapy for Hypertension and Dyslipidemia
Antihypertensive and hypolipidemic therapy reduces the risk of cardiovascular (CV) diseases. Observational studies have shown that factors of a healthy lifestyle also have this influence. But is the benefit of pharmacotherapy for hypertension and dyslipidemia influenced by adherence to a healthy lifestyle? This question was attempted to be answered by an analysis of data from the clinical study HOPE-3.
News Through Obstacles to the Stars – Path to Developing a Healthy Gut Microbiota in Children: What Blocks It and What Helps?
The gut microbiota is acquired by an individual during the first 2 years of life. The main source is the mother’s microbiota. Obstacles to the formation of an adequate microbiota include inappropriate composition of the mother’s microbiota, absence of vaginal birth and breastfeeding, as well as artificial feeding and antibiotic treatment in the child. We provide a summary of current findings on the adverse effects of planned cesarean sections on the child’s microbiome, as recently published in Critical Reviews in Microbiology.
News Early Cytoreductive Treatment Delays Onset of Symptoms Associated with Metastatic Colorectal Carcinoma
Managing symptoms associated with advanced cancer has a significant impact on patients' quality of life and influences decisions about appropriate therapy for an individual patient. An international team of authors conducted a retrospective analysis of 3 clinical trials of the anti-epidermal growth factor receptor (EGFR) antibody panitumumab in the treatment of metastatic colorectal carcinoma (mCRC) and assessed the relationship between tumor response to treatment and the occurrence of symptoms associated with the tumor.
News Itoprid helps diabetics with reduced gastrointestinal motility improve diabetes control
The prokinetic itoprid led not only to the alleviation of gastroparesis symptoms and an improvement in quality of life in a prospective multicenter observational study on patients with diabetes and reduced gastrointestinal (GI) motility, but also to an improvement in glycemic parameters.
News Can tofacitinib have a positive impact on the mental stress of patients with rheumatoid arthritis?
In the population of patients with rheumatoid arthritis (RA), there is a higher incidence of depression and anxiety compared to the healthy population. These psychiatric comorbidities can lead to a reduced quality of life and a poorer response to treatment. The aim of the post-hoc analysis presented below was to monitor the effect of tofacitinib on improving anxiety and depression in patients with RA.
News Efficacy of Combination Therapy for Chronic Lymphocytic Leukemia in Patients with Complex Karyotype
A complex karyotype (presence of ≥ 3 chromosomal abnormalities) is a negative prognostic marker in chronic lymphocytic leukemia (CLL). An analysis of the impact of complex karyotype on the efficacy of targeted CLL therapy combining the monoclonal antibody against CD20 antigen obinutuzumab with the BCL2 inhibitor venetoclax or the alkylating cytostatic chlorambucil was published in the journal Blood.
News Recommendations for the diagnosis of ITP in adults and children according to ASH guidelines
The American Society of Hematology (ASH) guidelines from 2019 highlighted several important aspects in the diagnosis and treatment of ITP that have remained unchanged from the 2011 guidelines.
News Current ASH Guidelines on ITP Management 2019 – Recommendations for Newly Diagnosed ITP in Children
At the end of 2019, the American Society of Hematology (ASH) published current guidelines for immune thrombocytopenia (ITP), in which a panel of experts attempted to define evidence-based recommendations for the care management of these patients.
News Clinical Results of the Pinnacle Acetabular System: Data from the UK Joint Replacement Registry
The Pinnacle Acetabular System has been available on the market for nearly two decades. Since then, it has been implanted in numerous healthcare facilities worldwide. Clinical outcomes of the acetabular system were evaluated by analyzing data from the National Joint Replacement Registry of England, Wales, Northern Ireland, and the Isle of Man.
News Positive Effect of Diosmin on Venous Disease in Terms of Factors Responsible for Angiogenesis
A study published last year monitored the impact of diosmin on laboratory and clinical parameters related to the pathophysiology of chronic venous disease in patients.
News Obinutuzumab and Early Progression of Patients with Previously Untreated Follicular Lymphoma − Analysis of Data from the GALLIUM Study
The GALLIUM study demonstrated longer progression-free survival (PFS) in patients with previously untreated follicular lymphoma (FL) treated with obinutuzumab compared to rituximab. The aim of the exploratory data analysis was to evaluate the impact of obinutuzumab on the incidence of early disease progression and the relationship between early progression and overall survival (OS) of the patients.
News The Benefit of Dabigatran Over Warfarin Is Greater in Patients with Atrial Fibrillation and Diabetes Than in Nondiabetics
As early as 2015, an analysis of the results of the RE-LY study in patients with atrial fibrillation showed that the reduction in absolute risk of embolic events with dabigatran compared to warfarin is greater in patients with diabetes than in those without diabetes.
News Impact of Dabigatran and Warfarin Treatment on the Risk of Acute Kidney Injury in Patients with Atrial Fibrillation
What clinical characteristics in patients with non-valvular atrial fibrillation may indicate a higher risk of acute kidney injury? Does the modality of anticoagulation therapy play a role in its incidence? These questions were the focus of an extensive retrospective study conducted in an Asian setting.
News High-Dose Cyclophosphamide in Hard-to-Treat Patients with B-NHL
For hard-to-treat patients with non-Hodgkin lymphoma, cyclophosphamide administered in one or two cycles can help bridge the period needed to obtain other effective treatments, as inferred from the work of French authors recently published in the European Journal of Haematology.