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Články časopisu Global Allergy and Asthma European Network (GA²LEN) addresses the epidemic of allergy and asthma

Author of the article: Petr Panzner, Petr Čáp, Peter Burney, Torsten Zuberbier, Paul Van Cauvenberg, Jean Bousquet Source: Časopis lékařů českých | 1/2010 1. 1. 2010

News You can confirm or exclude ATTRv amyloidosis through genetic testing

Source: Rare Diseases 16. 3. 2022

News Current Options and Prospects for Effective Antiemetic Treatment in an Effort to Increase Adherence of Oncological Patients to Chemotherapy

Chemotherapy-induced nausea and vomiting (CINV) is strongly associated with treatment in the minds of many oncology patients, and its occurrence is rated as one of the most dreaded and stressful complications. For most patients, adherence to recommendations for antiemetic prophylaxis can successfully prevent the occurrence of CINV. A review article published last year by an international team of authors in the journal Future Oncology provides an overview of the current spectrum of options in CINV prophylaxis, focusing on the first combined preparation in this indication, containing the active substances netupitant and palonosetron.

Source: Antiemetic Therapy 31. 3. 2020

Články časopisu Why do we still hesitate to accept the new international criteria for the diagnosis of gestational diabetes mellitus?
The current screening is non-uniform and does not correspondwith evidence-based medicine

Author of the article: Hana Krejčí, Kateřina Anderlová Source: Česká gynekologie | 3/2014 18. 6. 2014

News Multiparametric Magnetic Resonance in Predicting Progression of Low-Risk Prostate Cancer

A newly published study has demonstrated the utility of imaging using multiparametric magnetic resonance imaging (mpMRI) and its interpretation using PI-RADS version 2 (Prostate Imaging Reporting and Data System) in predicting unfavorable disease outcomes in patients with prostate cancer suitable for active surveillance.

Source: Prostate Health Index 4. 6. 2020

News Case of Heparin Allergy and Preventive Administration of Fondaparinux in Pregnancy –⁠ Case Study

The presented case study discusses a complicated case of a 40-year-old woman with essential thrombocythemia (ET), a history of intrauterine fetal death, and recurrent pulmonary embolism (PE). The patient developed an allergic reaction to low-molecular-weight heparin (LMWH) and was successfully managed with fondaparinux during pregnancy.

Source: Management of Thrombosis in Women 20. 5. 2021

News Fixed combination tiotropium/olodaterol in regular clinical practice: What do patients say?

A non-interventional international study assessed the therapeutic benefits of the fixed combination of tiotropium/olodaterol in the treatment of chronic obstructive pulmonary disease (COPD) in real-world practice through a questionnaire filled out by patients.

Source: COPD 28. 5. 2021

News Dressing Solutions for Better Wound Care

Although wounds at different stages of healing require different types of treatment, the essential part of any dressing change is cleaning the wound and its surroundings from tissue debris and microorganisms and protecting it from reinfection. Modern dressing solutions facilitate easy cleaning and moisturizing of wounds. Effective treatment also brings clinical and economic benefits.

Source: Wound Healing 19. 3. 2023

News Bimekizumab in the Treatment of Psoriatic Arthritis

Arthritis can appear in up to a third of patients with psoriasis, mostly after the onset of skin symptoms. Early recognition of this transition by dermatologists and general practitioners is crucial, as early intervention can prevent irreversible joint damage. In the context of effective biological therapy, there is even talk of the potential prevention of arthritis development in individuals with psoriasis.

Source: Rheumatic Diseases 20. 6. 2024

News Estimated Worldwide Prevalence of Population with AAT Deficiency with MZ Alleles

Alpha-1-antitrypsin deficiency (AATD) with the MZ genotype was until recently associated with negligible or low risk for lung and liver tissue damage. However, growing evidence suggests that carriers of MZ alleles are at increased risk of organ damage when exposed to tobacco smoke, polluted air, or hepatotoxic substances. Moreover, according to a global epidemiological study, the prevalence of the MZ genotype is very common, especially among Caucasians in Europe and other continents.

Source: Deficiency of Alpha-1-Antitrypsin 14. 11. 2022

News Key Role of HRCT in Diagnosing Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis is often an unjustly overlooked disease. The truth is that it is a rare disease, but the prognosis for patients is very poor. To improve quality of life and chances of longer survival, early diagnosis is crucial, with imaging methods, specifically high-resolution computed tomography (HRCT), playing a key role.

Source: Pulmonary Fibrosis 15. 4. 2020

News Current (and Future) Possibilities for Diagnosing Alpha-1-Antitrypsin Deficiency

Alpha-1-antitrypsin deficiency (AAT) is associated, among other things, with the development of chronic obstructive pulmonary disease (COPD) with emphysema. Most patients, however, remain undiagnosed and therefore do not receive adequate treatment. Below we summarize the current possibilities for diagnosing this genetic disorder.

Source: Deficiency of Alpha-1-Antitrypsin 25. 2. 2022

News Experiences with treating PBC with obeticholic acid in Brno's CKTCH

MUDr. Libuše Husová, Ph.D., shared the current insights from the therapy of patients with primary biliary cholangitis (PBC) using obeticholic acid (OCA) gained at the Center for Cardiovascular and Transplantation Surgery in Brno (CKTCH) during the XLVIII May Hepatology Days.

Source: Primary Biliary Cholangitis 22. 7. 2021

News How to Most Effectively Delay Skeletal Events in Patients with Bone Metastases from Solid Tumors?

In a randomized Phase III study, the effectiveness of denosumab and zoledronic acid in preventing skeletal events in patients with multiple myeloma or solid tumors (excluding breast and prostate cancer) and bone metastases was evaluated. An ad hoc analysis of this study then involved only a subgroup of patients with solid tumors.

Source: Prevention of Bone Events 12. 9. 2022

News Fixed combinations of Enerzair® and Atecura® may improve asthma treatment

The newly approved fixed triple combination Enerzair® and the fixed dual combination Atectura® have demonstrated improvements in lung function and a reduction in exacerbations in previously uncontrolled asthma patients. Administering once daily using the Breezhaler® inhaler along with the possibility of connecting a digital aid aims, among other things, to facilitate usage and proper adherence to the treatment.

Source: Asthma under control 24. 2. 2021

Články časopisu Global Allergy and Asthma European Network (GA2LEN) addresses the epidemic of allergy and asthma