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News Brain Metastases Are Not an Absolute Contraindication for Antiplatelet Therapy

On one hand, there's a higher risk of thromboembolic events, and on the other, a higher risk of intracranial bleeding. Prophylactic and therapeutic interventions for blood clotting are necessary for cancer patients in indicated cases. But what about the risk of bleeding in patients with CNS malignancies?

Source: Genetic Profile and Treatment of NSCLC 27. 12. 2021

News Vaccination Against COVID-19 in Patients Treated With Anticoagulants

Canadian professional societies and the National Health Service (NHS) in the United Kingdom recommend COVID-19 vaccination even for patients treated with anticoagulants. The benefit of vaccination in these patients significantly outweighs the risk of hematoma associated with intramuscular injection. The recommendation applies to both warfarin and direct oral anticoagulants (DOACs).

Source: Anticoagulant Treatment 11. 10. 2021

Články časopisu Can contraception to impact demographics dates?

Author of the article: doc. MUDr. Tomáš Fait, Ph.D Source: Praktická gynekologie | 4/2013 13. 12. 2013

News Central European Expert Consensus on the Treatment of ITP in Adult Patients

In a recently published consensus, experts from Central Europe evaluate the current treatment options for immune thrombocytopenia (ITP) in adult patients and issue 7 recommendations for the administration of thrombopoietin receptor agonists (TPO-RA) in the 2nd line treatment of ITP, based on an analysis of 31 randomized controlled trials.

Source: Immune Thrombocytopenia 15. 4. 2024

News Economic Burden and Loss of Quality of Life as a Consequence of Dry Eye Syndrome

Canadian authors evaluated the direct and indirect financial costs associated with dry eye syndrome (DED −⁠ dry eye disease) and the impact of this condition on the quality of life (QoL) of patients. The results were stratified according to the severity of the condition. The most significant was the loss of work productivity, highlighting the need for adequate solutions for DED.

Source: Treatment of Glaucoma 1. 4. 2024

News Interactive Case Study of a Patient with Severe Hemophilia A -⁠ Experience from Slovenia

Assoc. Prof. Dr. Irena Preložnik Zupan (University Medical Centre Ljubljana) describes an interactive case study of a patient with severe hemophilia A and progressive cataracts in both eyes.

Source: Quality Life Even with Hemophilia 24. 3. 2021

News Pegylated Liposomal Irinotecan + 5-FU/LV in the Treatment of mPDAC in Czech Clinical Practice –⁠ Results from the VILP Registry

At last year's annual congress of the European Society for Medical Oncology (ESMO) and this year's 15th PragueONCO, results from the Czech VILP registry were presented. This registry collected data on patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) treated with pegylated liposomal irinotecan (nal-IRI) in combination with 5-fluorouracil (5-FU) and leucovorin (LV). The efficacy and safety of nal-IRI + 5-FU/LV in patients with mPDAC after failure or intolerance to gemcitabine-based chemotherapy, as found in the randomized controlled study NAPOLI-1, are thus confirmed in real clinical practice in the Czech Republic.

Source: Treatment of Gastrointestinal Carcinomas 25. 3. 2024

News Comorbidities of Migraine and Their Impact on Pain Frequency and Intensity

The MAST study, published in March of this year in the prestigious The Journal of Headache and Pain, focused on the occurrence of associated diseases in patients with migraine. What is the prevalence of individual comorbidities and which of them are associated with changes in pain intensity and frequency?

Source: Migraine 27. 7. 2020

News Is it possible to extend the life of diabetics thanks to modern treatment?

People aged 60 with type 2 diabetes are estimated to live on average 6-7 years less compared to their peers without a diabetes diagnosis. However, clinical study results suggest that modern therapy can prevent these lost years.

Source: Diabetes 29. 4. 2022

News Impact of Prophylaxis on Reducing the Risk of Neurological Problems Associated with Bleeding in Hemophilia A

Bleeding can also cause complications in the nervous system of hemophiliacs. The authors of the work presented below discuss the significance of prophylactic administration of factor VIII coagulation concentrates, specifically concerning neurological complications related to bleeding.

Source: Hemophilia 14. 4. 2022

News Positive Effect of Pregabalin Not Only on Neuropathic Pain in Patients with Spinal Cord Injury

Spinal cord injury is often accompanied by painful conditions. A study published in the prestigious journal Neurology demonstrated that administering pregabalin to these patients can bring more than just pain relief.

Source: Neuropathic Pain 18. 2. 2020

News Prediction of Hypocalcemia Risk in Patients Treated with Denosumab and Active Form of Vitamin D

According to new work by Japanese authors, it appears that the risk factors for the development of hypocalcemia in patients treated with denosumab and calcitriol (the active form of vitamin D) are different from those when natural vitamin D is added to denosumab.

Source: Prevention of Bone Events 8. 6. 2023

News Therapy of Chronic Leg Ulcers According to Evidence-Based Medicine

Chronic ulcers on the lower extremities are defined as trophic defects that show no signs of healing after 3 months of appropriate treatment or are not healed even after 12 months of treatment. Their incidence and prevalence are continuously increasing, and they currently represent not only a serious medical problem but also a socioeconomic issue. An overview article published by German physicians focuses on summarizing the therapy of leg ulcers according to the principles of evidence-based medicine.

Source: Wound Healing 15. 11. 2020

News Efficacy and Safety of Fenfluramine in the Treatment of Lennox-Gastaut Syndrome –⁠ An Overview of Current Knowledge

In a recently published article, British authors summarize the current knowledge on the efficacy and safety of fenfluramine (FFA) in the treatment of Lennox-Gastaut syndrome (LGS, a developmental and epileptic encephalopathy). In addition to the reduction in seizure frequency demonstrated in clinical studies, they discuss the impact of fenfluramine on reducing the risk of sudden unexpected death in epilepsy (SUDEP), improving cognitive function in patients, and its safety concerning weight loss and heart disorders.

Source: Rare Diseases in Neurology 21. 6. 2024

News Efficacy and Safety of Dupilumab in the Treatment of Severe Asthma Insufficiently Controlled by Standard Therapy –⁠ Current Clinical Practice Data

If severe bronchial asthma with type 2 inflammation is insufficiently controlled by combined maintenance therapy, dupilumab –⁠ a recombinant monoclonal antibody inhibiting the signaling pathway of interleukins 4 and 13 –⁠ can be added. What is its efficacy in clinical practice? We summarize findings from 3 recent retrospective studies.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 16. 3. 2023