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News Efficacy and Safety of Dupilumab in the Treatment of Severe Asthma Insufficiently Controlled by Standard Therapy –⁠ Current Clinical Practice Data

If severe bronchial asthma with type 2 inflammation is insufficiently controlled by combined maintenance therapy, dupilumab –⁠ a recombinant monoclonal antibody inhibiting the signaling pathway of interleukins 4 and 13 –⁠ can be added. What is its efficacy in clinical practice? We summarize findings from 3 recent retrospective studies.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 16. 3. 2023

News Limits of Glycated Hemoglobin and the Importance of Other Glycated Proteins

Glycated hemoglobin is a gold standard in the diagnosis and management of diabetes treatment. However, its disadvantages include numerous factors that can cause false increases or decreases in its levels. Therefore, the scientific community is also interested in researching other glycated proteins that could be used in diabetes control. So, what should we keep in mind when collecting glycated hemoglobin?

Source: Modern Treatment of Diabetes 17. 2. 2022

News Memantine Eases Daily Life for Patients and Caregivers

What is the efficacy and safety of memantine in patients with Alzheimer's disease in routine practice in the Czech Republic? And to what extent can it ease the burden on caregivers of these patients?

Source: Cognitive in the treatment of Alzheimer's disease 12. 10. 2020

News Summary of Czech Recommendations for the Diagnosis and Treatment of Schizophrenia in Children and Adolescents 2022

In June 2022, the Psychiatric Society of the Czech Medical Association JEP updated its recommendations for the diagnosis and treatment of schizophrenia in children and adolescents. This is the first online version, which will allow for faster implementation of new findings important for clinical practice and decision-making by state institutions. We bring you a summary of the key points of these recommendations.

Source: Modern Treatment of Schizophrenia 21. 2. 2023

News Bacterial Biofilm as a Complication of Respiratory Disease Treatment

One of the unique characteristics of certain microorganisms is their ability to form organized communities enveloped in extracellular polymeric matrix and firmly attached to a solid surface or interphase or forming aggregates, collectively referred to as biofilm. Clinically, the major issue is the formation of pathogenic and conditionally pathogenic organisms' biofilm on tissues (such as respiratory tracts) or the surfaces of various medical devices (including catheters and implants), as it represents a dangerous complication leading to the development of chronic, recurrent, and scarcely treatable conditions.

Source: Cough Therapy 28. 11. 2023

News Improving treatment outcomes of HF with preserved ejection fraction according to JACC: What does the success of gliflozins mean for the future?

The Journal of the American College of Cardiology (JACC) recently issued a scientific statement in which the authors thoroughly examined current knowledge on the epidemiology, pathophysiology, diagnosis, and treatment of heart failure with preserved ejection fraction of the left ventricle (HFpEF). Recent studies in this heterogeneous disease suggest the importance of carefully determining the HFpEF phenotype in a given patient based on pathophysiology, which enables better individualization of treatment. The authors also reflect on the success of gliflozins in treating HFpEF and how HFpEF pharmacotherapy can be further improved.

Source: Heart Failure 4. 3. 2024

News Bimekizumab in 3rd Line Biological Treatment After Risankizumab Failure –⁠ Case Study

The possibilities of biological therapy for severe forms of psoriasis are very broad today. Achieving remission or reducing disease activity by 90-100% from the baseline state (PASI 90-100) is highly probable, especially when using biological drugs from the IL-17 or IL-23 inhibitor groups. However, individually, patients may exhibit primary or secondary resistance even when using these preparations, necessitating a change in biological treatment. The following case study presents the case of a young man who achieved complete disease remission with bimekizumab after the previous failure of ixekizumab and risankizumab.

Source: Psoriasis 22. 3. 2024

Články časopisu Small cell lung cancer –⁠ news in the tumour´s biology

Author of the article: Klára Pavlíčková, Radoslav Matěj Source: Česko-slovenská patologie | 1/2023 18. 4. 2023

News Can We Lump All Gabapentinoids Together?

General practitioners often encounter peripheral neuropathic pain in their practice. One of the primary modalities for treating both painful diabetic neuropathy and postherpetic neuralgia is gabapentinoids, specifically gabapentin and pregabalin. Are these substances completely interchangeable, or do their efficacy and practical application differ?

Source: Neuropathic Pain 18. 2. 2020

Články časopisu BENIGN DERMATOSIS OF PENIS

Author of the article: MUDr. David Němec Source: Urologické listy | 4/2005 4. 1. 2006

News Carpal Tunnel Syndrome as a Warning Sign of Cardiomyopathy Caused by Transthyretin Amyloidosis

Recent study results suggest that transthyretin amyloidosis is a more common cause of heart failure than previously thought. Early diagnosis and subsequent therapy are key to improving patient prognosis. A comprehensive study evaluating data from the Danish population registry suggests that carpal tunnel syndrome may be one of the initial symptoms of the disease.

Source: Amyloidosis 2. 3. 2023

News Therapy of Chronic Leg Ulcers According to Evidence-Based Medicine

Chronic ulcers on the lower extremities are defined as trophic defects that show no signs of healing after 3 months of appropriate treatment or are not healed even after 12 months of treatment. Their incidence and prevalence are continuously increasing, and they currently represent not only a serious medical problem but also a socioeconomic issue. An overview article published by German physicians focuses on summarizing the therapy of leg ulcers according to the principles of evidence-based medicine.

Source: Wound Healing 15. 11. 2020

News Nutritional Therapy for Critically Ill Patients in the ICU –⁠ Current Recommendations

Critically ill patients hospitalized in the intensive care unit (ICU) require nutritional support to maintain adequate energy intake. Only by doing so can their clinical condition be prevented from worsening. Therefore, we summarize the current recommendations regarding nutritional therapy as part of care in the ICU in the following text.

Source: Parenteral Nutrition 4. 10. 2021

Články časopisu Possible prevention of Alzheimer’s disease

Author of the article: J. Janoutová, M. Kovalová, P. Ambroz, O. Machaczka, A. Zatloukalová, K. Němček, E. Mrázková, O. Košta, D. Školoudík, V. Janout Source: Česká a slovenská neurologie a neurochirurgie | 1/2020 5. 2. 2020

News Pregabalin can be chosen as the 1st line treatment for postherpetic neuralgia

The efficacy of pregabalin in patients with postherpetic neuralgia has been demonstrated in 4 multicenter randomized double-blind placebo-controlled studies.

Source: Neuropathic Pain 22. 6. 2020