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News Minimally Invasive Treatment of Pilonidal Sinus: Laser and Negative Pressure Therapy as a Gentle and Effective Modality

The increasing incidence of pilonidal sinus contributes to the development of new treatment methods. Experiences from AGEL Hospital Přerov show that the methods SiLaC (sinus laser ablation of the cyst) and NPWT (negative pressure wound therapy) represent a gentle and effective approach for pilonidal sinus, accelerating treatment and subsequent recovery.

Source: Wound Healing 24. 11. 2023

News Current View on Gestational Diabetes Mellitus in Theory and Practice

We dedicated one of the episodes of our podcast meditalks+ to the issue of gestational diabetes mellitus (GDM), focusing on aspects of care related to general practitioners. In a conversation with Associate Professor MUDr. Ludmila Brunerová, Ph.D., from the Diabetology Center at the Faculty Hospital Královské Vinohrady in Prague, we now continue with a more detailed look at selected questions that will also interest specialists.

Source: Modern Treatment of Diabetes 7. 9. 2023

News Diabetic Foot Syndrome: An Unpleasant Scare for Diabetics and Their Attending Doctors

Diabetic foot syndrome is a very serious complication of diabetes mellitus (DM). It often leads to destructive tissue damage distal to the ankle. Due to the complex therapy, it is advisable to focus on thorough and meticulous prevention of this complication.

Source: Diabetes 8. 3. 2021

News Proton radiotherapy means lower risk with high efficacy of radiation. The key is getting the patient into the treatment process as soon as possible

The Proton Therapy Center in Prague (PTC −⁠ Proton Therapy Center Czech) is a modern healthcare facility specializing in the treatment of oncological diseases using so-called proton radiotherapy. This therapy is covered by public health insurance in indicated cases. Since its opening in 2012, PTC has treated nearly 10,000 patients, not only from the Czech Republic and Slovakia. In 2019, it became part of the National Oncology Center.

Source: Proton Radiotherapy 8. 2. 2023

Články časopisu Treatment of pelvic avulsion fractures in children and adolescents

Author of the article: A. Stančák, J. Kautzner, T. Trč, V. Havlas Source: Rozhledy v chirurgii | 4/2017 23. 5. 2017

News Efficacy and Safety of Teriflunomide in the Treatment of Multiple Sclerosis in Children –⁠ Results of the TERIKIDS Study

Therapeutic options for multiple sclerosis in the pediatric population are limited. However, in June 2021, teriflunomide was approved for the treatment of relapsing-remitting multiple sclerosis (RRMS) in pediatric patients aged 10–17 years in the European Union. The basis for this registration was the favorable results of the TERIKIDS study, which we summarize below. Teriflunomide thus became the first oral medication for 1st line treatment of RRMS in children and adolescents within the EU.

Source: Multiple Sclerosis 1. 6. 2022

Články časopisu Prevention of TEN in surgery, prolonged thromboprophylaxis

Author of the article: Z. Krška Source: Rozhledy v chirurgii | 5/2012 30. 5. 2012

News How to Prevent and Treat Thromboembolic Disease in Cancer Patients

Malignancy is one of the risk factors for the development of thromboembolic disease (TED). Venous thromboembolism is considered the second most common cause of death in cancer patients, with the top cause being the cancer itself. Therefore, optimal treatment and timely prevention of these complications is very important.

Source: Thromboprophylaxis 6. 3. 2021

News Metamizole in Pain Therapy in the General Practitioner and Pediatric Office

Metamizole is a pyrazole analgesic-antipyretic with spasmolytic effects, indicated for the treatment of post-traumatic or postoperative pain, visceral colic, cancer pain, and high fever unresponsive to other treatments. The advantage of this drug is its good tolerance without serious adverse effects on the gastrointestinal system, no impact on platelet aggregation, and usability in adults and children of all ages.

Source: Updates in Pain Treatment 30. 3. 2023

News Reference Intervals of Prostate Health Index (PHI) in Healthy Men

For more specific prostate cancer screening, apart from prostate-specific antigen (PSA), its free fraction (fPSA) and one of its precursors, [-2]proPSA (p2PSA), are used today. From these parameters, the so-called Prostate Health Index (PHI) can be calculated. However, reference intervals for these parameters in a healthy population were not known until now.

Source: Prostate Health Index 2. 4. 2020

News Targeting HER2 is Clinically Meaningful Even with Its Low Expression

Distinguishing HER2 receptor expression status on the surface of breast cancer tumor cells as simply positive or negative is now proving insufficient. Ultimately, it can lead to the non-administration of effective targeted therapy. What do we actually know about the “gray zone” between HER2 positivity and negativity?

Source: Ovarian and Breast Cancer 22. 5. 2024

News Diagnosis and Management of Interstitial Lung Processes Associated with Rheumatoid Arthritis

Interstitial lung processes (ILD) are common yet insufficiently diagnosed complications of rheumatoid arthritis (RA), significantly increasing the morbidity and mortality of patients. ILD can occur at any stage of RA, presenting a diverse clinical picture. Usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP) are the most common findings on high-resolution CT (HRCT). Some patients with RA-associated ILD may exhibit a progressive phenotype characterized by expanding fibrotic changes on HRCT, declining lung function, worsening respiratory symptoms, and early mortality. A recently published review summarizes strategies for screening, monitoring, and managing ILD in RA.

Source: Progressive Interstitial Pulmonary Processes 3. 1. 2024

News Desirable Side Effects of Antidiabetics

The days when diabetology was a field solely focused on normalizing blood sugar levels are long gone. Today, the approach in diabetology increasingly prioritizes influencing the patient's overall life prognosis, particularly reducing cardiovascular risk. What can be the desirable side effects of the main groups of antidiabetics that are not related to merely lowering glucose levels?

Source: Diabetes 6. 11. 2020

News How to Set Individual Treatment Goals for Type 2 Diabetes?

Treatment goals for type 2 diabetes should always be set individually. In practice, this mainly involves an indicator of the success of long-term compensation –⁠ glycated hemoglobin (HbA_1c). Recommendations for the diagnosis and treatment of diabetes for general practitioners from 2020 list different target HbA_1c values according to the risk of hypoglycemia and other parameters. They also recall different target values for fit, frail, and dependent seniors.

Source: Diabetes 28. 8. 2020

Články časopisu Neonatal seizures –⁠ current view of the issue

Author of the article: K. Španělová, K. Česká, H. Ošlejšková, Š. Aulická Source: Česká a slovenská neurologie a neurochirurgie | 1/2020 5. 2. 2020